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Quinoxaline, its derivatives and applications: A state of the art review

2015-06-05Journal article Restricted access
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dc.contributor.authorAlmeida, Joana
dc.contributor.authorPessoa, Ana M.
dc.contributor.authorCordeiro, M. Natália D. S.
dc.contributor.authorFernandes, Rúben
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorNoronha, João Paulo
dc.contributor.authorVieira, Mónica
dc.date.accessioned2021-11-22T12:25:56Z
dc.date.available2021-11-22T12:25:56Z
dc.date.issued2015-06-05
dc.description.abstractQuinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perform. In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPereira, J. A., Pessoa, A. M., Cordeiro, M. N. D. S., Fernandes, R., Prudêncio, C., Noronha, J. P., & Vieira, M. (2015). Quinoxaline, its derivatives and applications: A State of the Art review. European Journal of Medicinal Chemistry, 97, 664-672. https://doi.org/https://doi.org/10.1016/j.ejmech.2014.06.058pt_PT
dc.identifier.doi10.1016/j.ejmech.2014.06.058pt_PT
dc.identifier.issn0223-5234
dc.identifier.urihttp://hdl.handle.net/10400.22/18919
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S022352341400587Xpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectQuinoxalinept_PT
dc.subjectQuinoxaline derivativespt_PT
dc.subjectBiological activitypt_PT
dc.subjectTherapeutic applicationpt_PT
dc.subjectBiomedical applicationspt_PT
dc.titleQuinoxaline, its derivatives and applications: A state of the art reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage672pt_PT
oaire.citation.startPage664pt_PT
oaire.citation.titleEuropean Journal of Medicinal Chemistrypt_PT
oaire.citation.volume97pt_PT
person.familyNameALMEIDA
person.familyNameFernandes
person.familyNamePrudêncio
person.familyNameVieira
person.givenNameJOANA
person.givenNameRúben
person.givenNameCristina
person.givenNameMónica
person.identifier635792
person.identifier1200571
person.identifier.ciencia-id1317-637D-8EE0
person.identifier.ciencia-id0D1F-4090-E82A
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.orcid0000-0001-8043-9053
person.identifier.orcid0000-0001-8933-3984
person.identifier.orcid0000-0002-9920-936X
person.identifier.orcid0000-0002-9614-9031
person.identifier.ridD-8977-2016
person.identifier.scopus-author-id57640135700
person.identifier.scopus-author-id6508057930
person.identifier.scopus-author-id24464652500
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery5ec466aa-7e58-47b6-a45b-b9ee3e6f6552

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