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Building on Surface-Active Ionic Liquids for the Rescuing of the Antimalarial Drug Chloroquine

2020Journal article Open access
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dc.contributor.authorSilva, Ana Teresa
dc.contributor.authorLis, Lobo
dc.contributor.authorOliveira, Isabel S.
dc.contributor.authorGomes, Joana
dc.contributor.authorTeixeira, Cátia
dc.contributor.authorNogueira, Fátima
dc.contributor.authorMarques, Eduardo F.
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorGomes, Paula
dc.date.accessioned2020-12-04T11:16:57Z
dc.date.available2020-12-04T11:16:57Z
dc.date.issued2020
dc.description.abstractIonic liquids derived from classical antimalarials are emerging as a new approach towards the cost-effective rescuing of those drugs. Herein, we disclose novel surface-active ionic liquids derived from chloroquine and natural fatty acids whose antimalarial activity in vitro was found to be superior to that of the parent drug. The most potent ionic liquid was the laurate salt of chloroquine, which presented IC50 values of 4 and 110 nM against a chloroquine-sensitive and a chloroquine-resistant strain of Plasmodium falciparum, respectively, corresponding to an 11- and 6-fold increase in potency as compared to the reference chloroquine bisphosphate salt against the same strains. This unprecedented report opens new perspectives in both the fields of malaria chemotherapy and of surface-active ionic liquids derived from active pharmaceutical ingredients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, A. T. L., L.; Oliveira, I.S.; Gomes, J.; Teixeira, C.; Nogueira, F.; Marques, E.F.; Ferraz, R.; Gomes, P. (2020). Building on Surface-Active Ionic Liquids for the Rescuing of the Antimalarial Drug Chloroquine. International Journal of Molecular Sciences, 21(15), 5334. https://doi.org/https://doi.org/10.3390/ijms21155334pt_PT
dc.identifier.doi10.3390/ijms21155334pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/16528
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/21/15/5334pt_PT
dc.subjectAntimalarialpt_PT
dc.subjectChloroquinept_PT
dc.subjectIonic liquidpt_PT
dc.subjectMalariapt_PT
dc.subjectRescuingpt_PT
dc.subjectRepurposingpt_PT
dc.subjectSurface activept_PT
dc.titleBuilding on Surface-Active Ionic Liquids for the Rescuing of the Antimalarial Drug Chloroquinept_PT
dc.typejournal article
dspace.entity.typePublication
person.familyNameFerraz
person.givenNameRicardo
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.orcid0000-0002-1761-117X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication.latestForDiscoverya5a8faa7-12a5-4b1c-bced-44c895677397

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