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Osteoporotic hip fractures: Bisphosphonates sales and observed turning point in trend. A population-based retrospective study

2013Journal article Open access
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dc.contributor.authorAlves, Sandra Maria
dc.contributor.authorEconomou, Theodoros
dc.contributor.authorOliveira, Carla Maria
dc.contributor.authorRibeiro, Ana Isabel
dc.contributor.authorNeves, Nuno
dc.contributor.authorGoméz-Barrena, Enrique
dc.contributor.authorPina, Maria de Fátima
dc.date.accessioned2015-05-25T10:21:17Z
dc.date.available2015-05-25T10:21:17Z
dc.date.issued2013
dc.description.abstractThe aim is to examine the temporal trends of hip fracture incidence in Portugal by sex and age groups, and explore the relation with anti-osteoporotic medication. From the National Hospital Discharge Database, we selected from 1st January 2000 to 31st December 2008, 77,083 hospital admissions (77.4% women) caused by osteoporotic hip fractures (low energy, patients over 49 years-age), with diagnosis codes 820.x of ICD 9-CM. The 2001 Portuguese population was used as standard to calculate direct age-standardized incidence rates (ASIR) (100,000 inhabitants). Generalized additive and linear models were used to evaluate and quantify temporal trends of age specific rates (AR), by sex. We identified 2003 as a turning point in the trend of ASIR of hip fractures in women. After 2003, the ASIR in women decreased on average by 10.3 cases/100,000 inhabitants, 95% CI (− 15.7 to − 4.8), per 100,000 anti-osteoporotic medication packages sold. For women aged 65–69 and 75–79 we identified the same turning point. However, for women aged over 80, the year 2004 marked a change in the trend, from an increase to a decrease. Among the population aged 70–74 a linear decrease of incidence rate (95% CI) was observed in both sexes, higher for women: − 28.0% (− 36.2 to − 19.5) change vs − 18.8%, (− 32.6 to − 2.3). The abrupt turning point in the trend of ASIR of hip fractures in women is compatible with an intervention, such as a medication. The trends were different according to gender and age group, but compatible with the pattern of bisphosphonates sales.por
dc.identifier.citationAlves, S. M., Economou, T., Oliveira, C., Ribeiro, A. I., Neves, N., Goméz-Barrena, E., & Pina, M. F. (2013). Osteoporotic hip fractures: Bisphosphonates sales and observed turning point in trend. A population-based retrospective study. Bone, 53(2), 430–436. https://doi.org/10.1016/j.bone.2012.12.014
dc.identifier.doi10.1016/j.bone.2012.12.014
dc.identifier.urihttp://hdl.handle.net/10400.22/6087
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S8756328212014329por
dc.subjectBisphosphonatespor
dc.subjectOsteoporosispor
dc.subjectHip fracturespor
dc.subjectAnti-osteoporotic medicationpor
dc.subjectPopulation studiespor
dc.titleOsteoporotic hip fractures: Bisphosphonates sales and observed turning point in trend. A population-based retrospective studypor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage436por
oaire.citation.startPage430por
oaire.citation.titleBONEpor
oaire.citation.volume53por
person.familyNameAlves
person.familyNameOliveira
person.givenNameSandra Maria
person.givenNameCarla Maria
person.identifier2571691
person.identifier.ciencia-idCF1F-D1D5-6BC1
person.identifier.ciencia-id291F-1C8B-BBC7
person.identifier.orcid0000-0002-2318-7491
person.identifier.orcid0000-0002-4594-1723
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationf91e1151-4aad-4af3-9fef-970548be5f0c
relation.isAuthorOfPublicationa04f063b-e5de-4b9e-8979-62107b36b3b7
relation.isAuthorOfPublication.latestForDiscoverya04f063b-e5de-4b9e-8979-62107b36b3b7

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