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Advisor(s)
Abstract(s)
Patients on chronic hemodialysis therapy are at high risk for disturbed trace element status due to both the underlying disease and the hemodialysis process itself. Data on serum bromine levels in these patients are scarce. Using an ICP-MS analytical procedure, serum bromine levels were determined in a cohort of end-stage renal disease patients on chronic hemodialysis (n=57; 68.9±14.0 years old; male/female ratio: 1.37). The results were compared with those of a control group (individuals without evidence of kidney disease according to standard clinical laboratory criteria who attended the same clinical laboratory for routine analyses: n=59; 57.4±17.9 years old; male/female ratio: 0.90). Hemodialysis patients had much lower serum bromine levels than controls: 1086±244 vs. 4137±770 µg/L; P<0.0001. Bromine (bromide in plasma) showed to be extensively removed from plasma due to the hemodialysis process. The actual impact of this bromine “deficiency” is unknown. Bromine has not generally been considered an “essential” element, however, evidence of possible essentiality has been growing. In particular, bromine has been linked to brain metabolism: it is used as a sedative to induce sleep, increases in animals during hibernation as well as in sleeping humans; and a bromine compound with REM sleep-inducing and anti-choline esterase activities (1-methylheptyl gammabromoacetoacetate) was identified in human cerebrospinal fluid. On the other hand, estimates suggest that 40-85% of hemodialysis patients have sleep disorders, mainly insomnia. Thus, the possibility has been raised that the bromine “deficiency” found in these patients may be associated with sleep the disorders that affect them. This is an interesting hypothesis that requires further clinical investigation.
Description
Keywords
Low serum bromine
Citation
Duro, M., Novakova, G., Bonev, P., Azevedo, R., Couto, C., Pinto, E., & Almeida, A. (2022). Low serum bromine levels in chronic hemodialysis patients—Is there any clinical impact? Libro de resúmenes del XXVI Encontro Internacional Galego‐Portugués de Química., 588. https://www.colquiga.org/_files/ugd/398543_55f54cb41f0849d2b908563d15c992b5.pdf
Publisher
Colegio Oficial de Químicos de Galicia