Publication
Optical coherence tomography baseline predictors for initial best-corrected visual acuity response to intravitreal anti-vascular endothelial growth factor treatment in eyes with diabetic macular edema: the chartres study
| dc.contributor.author | B M Santos, Ana Rita | |
| dc.contributor.author | Costa, Miguel  | |
| dc.contributor.author | Schwartz, Christian | |
| dc.contributor.author | Alves, Dalila | |
| dc.contributor.author | Figueira, João | |
| dc.contributor.author | Silva, Rufino | |
| dc.contributor.author | Cunha-Vaz, Jose G | |
| dc.date.accessioned | 2019-12-06T14:01:26Z | |
| dc.date.available | 2019-12-06T14:01:26Z | |
| dc.date.issued | 2018-06 | |
| dc.description.abstract | Purpose: To identify baseline optical coherence tomography morphologic characteristics predicting the visual response to anti-vascular endothelial growth factor therapy in diabetic macular edema. Methods: Sixty-seven patients with diabetic macular edema completed a prospective, observational study (NCT01947881-CHARTRES). All patients received monthly intravitreal injections of Lucentis for 3 months followed by PRN treatment and underwent best-corrected visual acuity measurements and spectral domain optical coherence tomography at Baseline, Months 1, 2, 3, and 6. Visual treatment response was characterized as good (≥10 letters), moderate (5–10 letters), and poor (<5 or letters loss). Spectral domain optical coherence tomography images were graded before and after treatment by a certified Reading Center. Results: One month after loading dose, 26 patients (38.80%) were identified as good responders, 19 (28.35%) as Moderate and 22 (32.83%) as poor responders. There were no significant best-corrected visual acuity and central retinal thickness differences at baseline (P = 0.176; P = 0.573, respectively). Ellipsoid zone disruption and disorganization of retinal inner layers were good predictors for treatment response, representing a significant risk for poor visual recovery to anti-vascular endothelial growth factor therapy (odds ratio = 10.96; P < 0.001 for ellipsoid zone disruption and odds ratio = 7.05; P = 0.034 for disorganization of retinal inner layers). Conclusion: Damage of ellipsoid zone, higher values of disorganization of retinal inner layers, and central retinal thickness decrease are good predictors of best-corrected visual acuity response to anti-vascular endothelial growth factor therapy. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1097/IAE.0000000000001687 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.22/15058 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.relation.publisherversion | https://insights.ovid.com/pubmed?pmid=28613220 | pt_PT |
| dc.subject | Angiogenesis Inhibitors | pt_PT |
| dc.subject | Diabetic Retinopathy | pt_PT |
| dc.subject | Intravitreal Injections | pt_PT |
| dc.subject | Macular Edema | pt_PT |
| dc.subject | Predictive Value of Tests | pt_PT |
| dc.subject | Ranibizumab | pt_PT |
| dc.subject | Retina | pt_PT |
| dc.subject | Tomography, Optical Coherence | pt_PT |
| dc.subject | Vascular Endothelial Growth Factor A | pt_PT |
| dc.subject | Visual Acuity | pt_PT |
| dc.title | Optical coherence tomography baseline predictors for initial best-corrected visual acuity response to intravitreal anti-vascular endothelial growth factor treatment in eyes with diabetic macular edema: the chartres study | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 1119 | pt_PT |
| oaire.citation.issue | 6 | pt_PT |
| oaire.citation.startPage | 1110 | pt_PT |
| oaire.citation.title | RETINA | pt_PT |
| oaire.citation.volume | 38 | pt_PT |
| person.familyName | B M Santos | |
| person.givenName | Ana Rita | |
| person.identifier.ciencia-id | 291A-15C5-9C96 | |
| person.identifier.orcid | 0000-0003-3761-3292 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | cf304315-48a2-4bae-a1d5-61a4c8e45274 | |
| relation.isAuthorOfPublication.latestForDiscovery | cf304315-48a2-4bae-a1d5-61a4c8e45274 |