Repository logo
 
Publication

The antibacterial and angiogenic effect of magnesium oxide in a hydroxyapatite bone substitute

2020-11Journal article Open access
Simple item page
dc.contributor.authorCoelho, Catarina C.
dc.contributor.authorPadrão, Tatiana
dc.contributor.authorCosta, Laura
dc.contributor.authorPinto, Marta T .
dc.contributor.authorCosta, Paulo C.
dc.contributor.authorDomingues, Valentina F.
dc.contributor.authorQuadros, Paulo A.
dc.contributor.authorMonteiro, Fernando J.
dc.contributor.authorSousa, Susana R.
dc.date.accessioned2021-09-27T10:59:56Z
dc.date.available2021-09-27T10:59:56Z
dc.date.issued2020-11
dc.description.abstractBone graft infections are serious complications in orthopaedics and the growing resistance to antibiotics is increasing the need for antibacterial strategies. The use of magnesium oxide (MgO) is an interesting alternative since it possesses broad-spectrum antibacterial activity. Additionally, magnesium ions also play a role in bone regeneration, which makes MgO more appealing than other metal oxides. Therefore, a bone substitute composed of hydroxyapatite and MgO (HAp/MgO) spherical granules was developed using different sintering heat-treatment cycles to optimize its features. Depending on the sintering temperature, HAp/MgO spherical granules exhibited distinct surface topographies, mechanical strength and degradation profiles, that influenced the in vitro antibacterial activity and cytocompatibility. A proper balance between antibacterial activity and cytocompatibility was achieved with HAp/MgO spherical granules sintered at 1100 ºC. The presence of MgO in these granules was able to significantly reduce bacterial proliferation and simultaneously provide a suitable environment for osteoblasts growth. The angiogenic and inflammation potentials were also assessed using the in vivo chicken embryo chorioallantoic membrane (CAM) model and the spherical granules containing MgO stimulated angiogenesis without increasing inflammation. The outcomes of this study evidence a dual effect of MgO for bone regenerative applications making this material a promising antibacterial bone substitute.pt_PT
dc.description.sponsorshipThis work was financed by the project NoMIC2Bone (NORTE-01-0247-FEDER-017905) and project Biotherapies (NORTE-01-0145-FEDER-000012) supported by Norte Portugal Regional Operational Program (NORTE2020), under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund (ERDF). Financial supported was also obtained from FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalization (POCI), PORTUGAL 2020, and by Portuguese funds through FCT/MCTES in the framework of the project “Institute for Research and Innovation in Health Sciences”(POCI-01-0145-FEDER-007274). Fundação para a Ciência e Tecnologia (FCT) is also acknowledged for Catarina Coelho’s PhD grant (SFRH/BDE/108971/2015). This work was also supported by the Applied Molecular Biosciences Unit-UCIBIO, which is financed by national funds from FCT/MCTES (UID/Multi/04378/2019). The authors would also want to acknowledge Rui Rocha from CEMUP for the contribution with SEM analysis and Dra. Rosário Soares from the University of Aveiro for the help with XRD data.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1038/s41598-020-76063-9pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/18559
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Portfoliopt_PT
dc.relationPOCI-01-0145-FEDER-007274pt_PT
dc.relationDevelopment of antimicrobial nanohydroxyapatite spherical granules for bone tissue regeneration
dc.relationApplied Molecular Biosciences Unit
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-020-76063-9pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMagnesium oxidept_PT
dc.subjectHydroxyapatite bone substitutept_PT
dc.titleThe antibacterial and angiogenic effect of magnesium oxide in a hydroxyapatite bone substitutept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of antimicrobial nanohydroxyapatite spherical granules for bone tissue regeneration
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/48451/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/154717/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBDE%2F108971%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04378%2F2019/PT
oaire.citation.issue1pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamPOR_NORTE
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
oaire.fundingStream6817 - DCRRNI ID
person.familyNameDA SILVA PADRÃO
person.familyNameDomingues
person.givenNameTATIANA CRISTINA
person.givenNameValentina Maria Fernandes
person.identifier.ciencia-id331D-C948-EA4F
person.identifier.ciencia-id4E16-791D-6664
person.identifier.orcid0000-0003-1198-8977
person.identifier.orcid0000-0003-3472-849X
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3f7f3a5a-d392-458e-9f57-613adeac888f
relation.isAuthorOfPublicationbe653ab6-34ec-4329-972a-eee990a7ec66
relation.isAuthorOfPublication.latestForDiscovery3f7f3a5a-d392-458e-9f57-613adeac888f
relation.isProjectOfPublication4f0a6770-4b26-4894-9cf4-560b8ae2e0db
relation.isProjectOfPublication22327fef-abac-4e83-9607-1cee6c29bede
relation.isProjectOfPublicationa44d7371-98f9-4d2f-a93b-edf6a77564aa
relation.isProjectOfPublication53b0fa2f-d610-41ad-aa17-1375097518c6
relation.isProjectOfPublication.latestForDiscovery22327fef-abac-4e83-9607-1cee6c29bede

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ART_GRAQ_SciReports2020.pdf
Size:
5.48 MB
Format:
Adobe Portable Document Format
Download

Collections

ISEP – GRAQ – Artigos