Publication
Systemic injections of Cannabidiol enhance Acetylcholine levels from basal forebrain in rats
dc.contributor.author | Murillo‑Rodríguez, Eric | |
dc.contributor.author | Arankowsky‑Sandoval, Glória | |
dc.contributor.author | Rocha, Nuno Barbosa | |
dc.contributor.author | Peniche‑Amante, Rodrigo | |
dc.contributor.author | Veras, André Barciela | |
dc.contributor.author | Machado, Sérgio | |
dc.contributor.author | Budde, Henning | |
dc.contributor.author | Rocha, Nuno | |
dc.date.accessioned | 2025-04-09T13:36:23Z | |
dc.date.available | 2025-04-09T13:36:23Z | |
dc.date.issued | 2018-06-06 | |
dc.description.abstract | Cannabis sativa is a plant that contains more than 500 components, of which the most studied are Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). Several studies have indicated that CBD displays neurobiological effects, including wake promotion. Moreover, experimental evidence has shown that injections of CBD enhance wake-related compounds, such as monoamines (dopamine, serotonin, epinephrine, and norepinephrine). However, no clear evidence is available regarding the effects of CBD on additional wake-related neurochemicals such as acetylcholine (ACh). Here, we demonstrate that systemic injections of CBD (0, 5, 10 or 30 mg/kg, i.p.) at the beginning of the lights-on period, increase the extracellular levels of ACh collected from the basal forebrain and measured by microdialysis and HPLC means. Moreover, the time course effects on the contents of ACh were present 5 h post-injection of CBD. Altogether, these data demonstrate that CBD increases ACh levels in a brain region related to wake control. This study is the first to show the effects of ACh levels in CBD-treated rats and suggests that the basal forebrain might be a site of action of CBD for wakefulness modulation. | por |
dc.description.sponsorship | CONACyT; Grant: CN-17-19 Grant: PresInvEMR2017 | |
dc.identifier.citation | Murillo-Rodríguez, E., Arankowsky-Sandoval, G., Rocha, N. B., Peniche-Amante, R., Veras, A. B., Machado, S., & Budde, H. (2018). Systemic Injections of Cannabidiol enhance Acetylcholine levels from basal forebrain in rats. Neurochemical Research, 43(8), 1511–1518. https://doi.org/10.1007/s11064-018-2565-0 | |
dc.identifier.doi | 10.1007/s11064-018-2565-0 | |
dc.identifier.eissn | 1573-6903 | |
dc.identifier.issn | 0364-3190 | |
dc.identifier.uri | http://hdl.handle.net/10400.22/29950 | |
dc.language.iso | eng | |
dc.peerreviewed | yes | |
dc.publisher | Springer | |
dc.relation.hasversion | https://link.springer.com/article/10.1007/s11064-018-2565-0 | |
dc.rights.uri | N/A | |
dc.subject | Cannabis | |
dc.subject | Dopamine | |
dc.subject | Monoamines | |
dc.subject | Sleep | |
dc.subject | Wakefulness | |
dc.title | Systemic injections of Cannabidiol enhance Acetylcholine levels from basal forebrain in rats | por |
dc.type | research article | |
dspace.entity.type | Publication | |
oaire.citation.endPage | 1518 | |
oaire.citation.startPage | 1511 | |
oaire.citation.title | Neurochemical Research | |
oaire.citation.volume | 43 | |
oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
person.familyName | Rocha | |
person.givenName | Nuno | |
person.identifier | 192266 | |
person.identifier.ciencia-id | AE16-A494-5F8B | |
person.identifier.orcid | 0000-0002-3139-2786 | |
person.identifier.rid | M-9821-2013 | |
person.identifier.scopus-author-id | 32867975300 | |
relation.isAuthorOfPublication | 9e940914-601a-4978-8d5b-74e5ade7ada7 | |
relation.isAuthorOfPublication.latestForDiscovery | 9e940914-601a-4978-8d5b-74e5ade7ada7 |