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Systemic injections of Cannabidiol enhance Acetylcholine levels from basal forebrain in rats

dc.contributor.authorMurillo‑Rodríguez, Eric
dc.contributor.authorArankowsky‑Sandoval, Glória
dc.contributor.authorRocha, Nuno Barbosa
dc.contributor.authorPeniche‑Amante, Rodrigo
dc.contributor.authorVeras, André Barciela
dc.contributor.authorMachado, Sérgio
dc.contributor.authorBudde, Henning
dc.contributor.authorRocha, Nuno
dc.date.accessioned2025-04-09T13:36:23Z
dc.date.available2025-04-09T13:36:23Z
dc.date.issued2018-06-06
dc.description.abstractCannabis sativa is a plant that contains more than 500 components, of which the most studied are Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). Several studies have indicated that CBD displays neurobiological effects, including wake promotion. Moreover, experimental evidence has shown that injections of CBD enhance wake-related compounds, such as monoamines (dopamine, serotonin, epinephrine, and norepinephrine). However, no clear evidence is available regarding the effects of CBD on additional wake-related neurochemicals such as acetylcholine (ACh). Here, we demonstrate that systemic injections of CBD (0, 5, 10 or 30 mg/kg, i.p.) at the beginning of the lights-on period, increase the extracellular levels of ACh collected from the basal forebrain and measured by microdialysis and HPLC means. Moreover, the time course effects on the contents of ACh were present 5 h post-injection of CBD. Altogether, these data demonstrate that CBD increases ACh levels in a brain region related to wake control. This study is the first to show the effects of ACh levels in CBD-treated rats and suggests that the basal forebrain might be a site of action of CBD for wakefulness modulation.por
dc.description.sponsorshipCONACyT; Grant: CN-17-19 Grant: PresInvEMR2017
dc.identifier.citationMurillo-Rodríguez, E., Arankowsky-Sandoval, G., Rocha, N. B., Peniche-Amante, R., Veras, A. B., Machado, S., & Budde, H. (2018). Systemic Injections of Cannabidiol enhance Acetylcholine levels from basal forebrain in rats. Neurochemical Research, 43(8), 1511–1518. https://doi.org/10.1007/s11064-018-2565-0
dc.identifier.doi10.1007/s11064-018-2565-0
dc.identifier.eissn1573-6903
dc.identifier.issn0364-3190
dc.identifier.urihttp://hdl.handle.net/10400.22/29950
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.relation.hasversionhttps://link.springer.com/article/10.1007/s11064-018-2565-0
dc.rights.uriN/A
dc.subjectCannabis
dc.subjectDopamine
dc.subjectMonoamines
dc.subjectSleep
dc.subjectWakefulness
dc.titleSystemic injections of Cannabidiol enhance Acetylcholine levels from basal forebrain in ratspor
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.endPage1518
oaire.citation.startPage1511
oaire.citation.titleNeurochemical Research
oaire.citation.volume43
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRocha
person.givenNameNuno
person.identifier192266
person.identifier.ciencia-idAE16-A494-5F8B
person.identifier.orcid0000-0002-3139-2786
person.identifier.ridM-9821-2013
person.identifier.scopus-author-id32867975300
relation.isAuthorOfPublication9e940914-601a-4978-8d5b-74e5ade7ada7
relation.isAuthorOfPublication.latestForDiscovery9e940914-601a-4978-8d5b-74e5ade7ada7

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