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Systemic injections of Cannabidiol enhance Acetylcholine levels from basal forebrain in rats

2018-06-06Research article Open access
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dc.contributor.authorMurillo‑Rodríguez, Eric
dc.contributor.authorArankowsky‑Sandoval, Glória
dc.contributor.authorRocha, Nuno Barbosa
dc.contributor.authorPeniche‑Amante, Rodrigo
dc.contributor.authorVeras, André Barciela
dc.contributor.authorMachado, Sérgio
dc.contributor.authorBudde, Henning
dc.contributor.authorRocha, Nuno
dc.date.accessioned2025-04-09T13:36:23Z
dc.date.available2025-04-09T13:36:23Z
dc.date.issued2018-06-06
dc.description.abstractCannabis sativa is a plant that contains more than 500 components, of which the most studied are Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). Several studies have indicated that CBD displays neurobiological effects, including wake promotion. Moreover, experimental evidence has shown that injections of CBD enhance wake-related compounds, such as monoamines (dopamine, serotonin, epinephrine, and norepinephrine). However, no clear evidence is available regarding the effects of CBD on additional wake-related neurochemicals such as acetylcholine (ACh). Here, we demonstrate that systemic injections of CBD (0, 5, 10 or 30 mg/kg, i.p.) at the beginning of the lights-on period, increase the extracellular levels of ACh collected from the basal forebrain and measured by microdialysis and HPLC means. Moreover, the time course effects on the contents of ACh were present 5 h post-injection of CBD. Altogether, these data demonstrate that CBD increases ACh levels in a brain region related to wake control. This study is the first to show the effects of ACh levels in CBD-treated rats and suggests that the basal forebrain might be a site of action of CBD for wakefulness modulation.por
dc.description.sponsorshipCONACyT; Grant: CN-17-19 Grant: PresInvEMR2017
dc.identifier.citationMurillo-Rodríguez, E., Arankowsky-Sandoval, G., Rocha, N. B., Peniche-Amante, R., Veras, A. B., Machado, S., & Budde, H. (2018). Systemic Injections of Cannabidiol enhance Acetylcholine levels from basal forebrain in rats. Neurochemical Research, 43(8), 1511–1518. https://doi.org/10.1007/s11064-018-2565-0
dc.identifier.doi10.1007/s11064-018-2565-0
dc.identifier.eissn1573-6903
dc.identifier.issn0364-3190
dc.identifier.urihttp://hdl.handle.net/10400.22/29950
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.relation.hasversionhttps://link.springer.com/article/10.1007/s11064-018-2565-0
dc.rights.uriN/A
dc.subjectCannabis
dc.subjectDopamine
dc.subjectMonoamines
dc.subjectSleep
dc.subjectWakefulness
dc.titleSystemic injections of Cannabidiol enhance Acetylcholine levels from basal forebrain in ratspor
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.endPage1518
oaire.citation.startPage1511
oaire.citation.titleNeurochemical Research
oaire.citation.volume43
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRocha
person.givenNameNuno
person.identifier192266
person.identifier.ciencia-idAE16-A494-5F8B
person.identifier.orcid0000-0002-3139-2786
person.identifier.ridM-9821-2013
person.identifier.scopus-author-id32867975300
relation.isAuthorOfPublication9e940914-601a-4978-8d5b-74e5ade7ada7
relation.isAuthorOfPublication.latestForDiscovery9e940914-601a-4978-8d5b-74e5ade7ada7

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