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Microencapsulation of the Biocide Benzisothiazolinone (BIT) by Inclusion in Methyl-β-cyclodextrin and Screening of Its Antibacterial and Ecotoxicity Properties

2024Journal article Open access
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datacite.subject.fosEngenharia e Tecnologia
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorSilva, Vânia F. M.
dc.contributor.authorSilva, Aurora
dc.contributor.authorGarrido, Ermelinda M. P. J.
dc.contributor.authorBorges, Fernanda
dc.contributor.authorGaspar, Alexandra
dc.contributor.authorGarrido, Jorge P. M. J.
dc.contributor.authorGarrido, E. Manuela
dc.contributor.authorSoares da Silva, Maria Aurora
dc.contributor.authorGarrido, Jorge
dc.contributor.editorLiu, Rutao
dc.date.accessioned2025-02-13T18:38:42Z
dc.date.available2025-02-13T18:38:42Z
dc.date.issued2024
dc.description.abstractThe excessive use of biocides has considerable environmental and economic impacts; this is why new technologies have been sought to decrease the concentration levels applied in an effort to reduce the use of these substances. Microencapsulation using cyclodextrins has been widely used in the food and pharmaceutical industries as a way of reducing the concentrations of the active substance necessary to achieve a biological effect and/or eliminate its irritating or toxicological effects. In this study, the inclusion complexation behavior and binding ability of benzothiazolinone (BIT) with different β-cyclodextrins (β-CD, HP-β-CD, and Me-β-CD) was investigated. The intermolecular interactions were examined through UV and FTIR spectroscopy, DSC, 1D 1H NMR, and 2D ROESY. The highest stability constant was observed for the BIT/Me-β-CD inclusion complex (299.5 ± 2.9 M−1). Antibacterial activity was investigated against Staphylococcus aureus and Escherichia coli, and the results revealed that the BIT/Me-β-CD inclusion complex displays a higher antibacterial activity than BIT. The acute toxicity of the biocide and inclusion complex was also examined using the photobacterium Aliivibrio fischeri. Although BIT exhibited higher toxicity than the inclusion complex, further investigation is needed due to the quorum quenching effect of β-CDs. The data found suggest that BIT microencapsulation can increase its aqueous solubility and can be used as an effective tool to improve its chemical, biological, and ecotoxicological properties.eng
dc.description.sponsorshipThis work was funded by FEDER funds through the Operational Programme Competitiveness Factors-COMPETE and national funds from the FCT—Foundation for Science and Technology under research grants (UIDB/00081/2020, DOI:10.54499/UIDB/00081/2020; LA/P/0056/2020, DOI: 10.54499/LA/P/0056/2020; EXPL/MED-QUI/1156/2021, DOI:10.54499/EXPL/MED-QUI/1156/2021); LA/P/0008/2020, DOI: 10.54499/LA/P/0008/2020; UIDB/50006/2020, DOI:10.54499/UIDB/50006/2020; UIDP/04730/2020, DOI:10.54499/UIDP/04730/2020. A. Gaspar gratefully acknowledges financial support received through contract DL 57/2016/CP1454/CT0008, DOI:10.54499/DL57/2016/CP1454/CT0008. V. Silva acknowledges her PhD grant to the project UIDP/04730/2020, DOI:10.54499/UIDB/04730/2020).
dc.identifier.citationSilva, V. F. M., Silva, A., Garrido, E. M. P. J., Borges, F., Gaspar, A., & Garrido, J. M. P. J. (2024). Microencapsulation of the Biocide Benzisothiazolinone (BIT) by Inclusion in Methyl-β-cyclodextrin and Screening of Its Antibacterial and Ecotoxicity Properties. Toxics, 12(9), 674. https://doi.org/10.3390/toxics12090674
dc.identifier.doi10.3390/toxics12090674
dc.identifier.issn2305-6304
dc.identifier.urihttp://hdl.handle.net/10400.22/29515
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationChemistry Research Unit of University of Porto
dc.relationCenter for Innovation in Industrial Engineering and Technology
dc.relation.hasversionhttps://www.mdpi.com/2305-6304/12/9/674
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectbiocidal active substances
dc.subjectisothiazolinone
dc.subjecthost-guest complex
dc.subjectencapsulation efficiency
dc.subjectbiological activity
dc.titleMicroencapsulation of the Biocide Benzisothiazolinone (BIT) by Inclusion in Methyl-β-cyclodextrin and Screening of Its Antibacterial and Ecotoxicity Propertieseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleChemistry Research Unit of University of Porto
oaire.awardTitleCenter for Innovation in Industrial Engineering and Technology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00081%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04730%2F2020/PT
oaire.citation.issue9
oaire.citation.titleToxics
oaire.citation.volume12
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGarrido
person.familyNameSoares da Silva
person.familyNameGarrido
person.givenNameE. Manuela
person.givenNameMaria Aurora
person.givenNameJorge
person.identifier1418356
person.identifier.ciencia-id0219-E083-0653
person.identifier.ciencia-id4A1F-0531-3943
person.identifier.orcid0000-0002-3892-4124
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person.identifier.orcid0000-0002-8066-360X
person.identifier.orcid0000-0001-8981-231X
person.identifier.orcid0000-0001-9050-6168
person.identifier.orcid0000-0002-8066-360X
person.identifier.orcid0000-0001-8981-231X
person.identifier.scopus-author-id7004992709
person.identifier.scopus-author-id57197468074
person.identifier.scopus-author-id7202779733
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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