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ABCB1 C1236T, G2677TA and C3435T genetic polymorphisms and antidepressant response phenotypes: results from a portuguese major depressive disorder cohort

2024-05-08Journal article Open access
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dc.contributor.authorSantos, Marlene
dc.contributor.authorLima, Luís
dc.contributor.authorCarvalho, Serafim
dc.contributor.authorBrandão, Andreia
dc.contributor.authorBarroso, Fátima
dc.contributor.authorCruz, Agostinho
dc.contributor.authorMedeiros, Rui
dc.date.accessioned2024-05-09T08:39:14Z
dc.date.available2024-05-09T08:39:14Z
dc.date.issued2024-05-08
dc.description.abstractP-glycoprotein (P-GP) is a transporter molecule expressed on the apical surface of capillary endothelial cells of the Blood–Brain Barrier (BBB), whose activity heavily influences drug distribution, including antidepressants. This transporter is encoded by ABCB1 gene, and genetic variations within ABCB1 gene have been proposed to affect drug efflux and have been previously associated with depression. In this context, we aimed to evaluate the role of C1236T, G2677TA and C3435T ABCB1 genetic polymorphisms in antidepressant treatment phenotypes from a cohort of patients harboring Major Depressive Disorder. Patients enrolled in the study consisted of 80 individuals with Major Depressive Disorder, who took part in a 27-month follow-up study at HML, Portugal. To investigate the correlation between ABCB1 polymorphisms and antidepressant response phenotypes, DNA was extracted from peripheral blood, and C1236T, C3435T and G2677TA polymorphisms were genotyped with TaqMan® SNP Genotyping Assays. Despite the fact that the evaluated polymorphisms (C1236T, C3435T and G2677TA) were not associated with treatment resistant depression, or relapse, we observed that patients carrying TT genotype of the C3435T polymorphism remit earlier than the ones carrying CC or CT genotypes (10.2 weeks vs. 14.9 and 21.3, respectively, p = 0.028, Log-rank test). Since we found an association with C3435T and time to remission, and not to the absence of remission, we suggest that this polymorphism could have an impact on antidepressant drug distribution, and thus influence on the time to remission will occur, without influencing the risk of remission itself.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, M., Lima, L., Carvalho, S., Brandão, A., Barroso, F., Cruz, A., & Medeiros, R. (2024). ABCB1 C1236T, G2677TA and C3435T genetic polymorphisms and antidepressant response phenotypes: Results from a portuguese major depressive disorder cohort. International Journal of Molecular Sciences, 25(10), Artigo 10. https://doi.org/10.3390/ijms25105112pt_PT
dc.identifier.doi10.3390/ijms25105112pt_PT
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10400.22/25488
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationFunding for this study was partially provided by AstraZeneca Foundation; the AstraZeneca Foundation had no further role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. This work received financial support from FCT/MCTES (UIDP/50006/2020 DOI 10.54499/UIDP/50006/2020) through national funds.pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/25/10/5112pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectABCB1pt_PT
dc.subjectPolymorphismspt_PT
dc.subjectAntidepressant phenotypespt_PT
dc.titleABCB1 C1236T, G2677TA and C3435T genetic polymorphisms and antidepressant response phenotypes: results from a portuguese major depressive disorder cohortpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume25(10)pt_PT
person.familyNameSantos
person.familyNameCruz
person.givenNameMarlene
person.givenNameAgostinho
person.identifier1508370
person.identifier.ciencia-id8311-B967-31C4
person.identifier.orcid0000-0001-5020-5942
person.identifier.orcid0000-0002-1157-8196
person.identifier.scopus-author-id57110502000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublicationd7ec3c5d-b3e0-4e34-8e24-4d1588876120
relation.isAuthorOfPublication.latestForDiscovery8ce9ee39-a4c6-46ae-99e2-49397b550f1b

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