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From the gut to the brain: Is microbiota a new paradigm in Parkinson’s disease treatment?

2024-04-30Journal article Open access
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dc.contributor.authorVilela, Cristiana
dc.contributor.authorAraújo, Bruna
dc.contributor.authorGuedes, Carla
dc.contributor.authorSilva, Rita Caridade
dc.contributor.authorMacedo, Joana Martins
dc.contributor.authorTeixeira, Catarina
dc.contributor.authorGomes, Eduardo
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorVieira, Mónica
dc.contributor.authorTeixeira, Fábio G.
dc.date.accessioned2024-10-09T09:59:36Z
dc.date.available2024-10-09T09:59:36Z
dc.date.issued2024-04-30
dc.description.abstractParkinson’s disease (PD) is recognized as the second most prevalent primary chronic neurodegenerative disorder of the central nervous system. Clinically, PD is characterized as a movement disorder, exhibiting an incidence and mortality rate that is increasing faster than any other neurological condition. In recent years, there has been a growing interest concerning the role of the gut microbiota in the etiology and pathophysiology of PD. The establishment of a brain–gut microbiota axis is now real, with evidence denoting a bidirectional communication between the brain and the gut microbiota through metabolic, immune, neuronal, and endocrine mechanisms and pathways. Among these, the vagus nerve represents the most direct form of communication between the brain and the gut. Given the potential interactions between bacteria and drugs, it has been observed that the therapies for PD can have an impact on the composition of the microbiota. Therefore, in the scope of the present review, we will discuss the current understanding of gut microbiota on PD and whether this may be a new paradigm for treating this devastating disease.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVilela, C., Araújo, B., Soares-Guedes, C., Caridade-Silva, R., Martins-Macedo, J., Teixeira, C., Gomes, E. D., Prudêncio, C., Vieira, M., & Teixeira, F. G. (2024). From the gut to the brain: Is Microbiota a new paradigm in Parkinson’s disease teatment? Cells, 13(9), Artigo 9. https://doi.org/10.3390/cells13090770pt_PT
dc.identifier.doi10.3390/cells13090770pt_PT
dc.identifier.eissn2073-4409
dc.identifier.urihttp://hdl.handle.net/10400.22/26221
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationThe present work was supported by Prémios Santa Casa Neurociências—Prize Mantero Belard for Neurodegenerative Diseases Research (MB-28-2019) by Santa Casa da Misericórdia de Lisboa, and the Portuguese Foundation for Science and Technology (FCT) to F.G.T. (2021.00643.CEECIND), B.A. (2022.13292.BD), C.S.-G. (2023.03466.BD), R.C.-S. (2022.13323.BD), J.M.-M. (2023.00893.BD), and C.T. (2022.12641.BD).pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2073-4409/13/9/770pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectParkinson’s diseasept_PT
dc.subjectMicrobiomept_PT
dc.subjectGut–brain axispt_PT
dc.titleFrom the gut to the brain: Is microbiota a new paradigm in Parkinson’s disease treatment?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleCellspt_PT
oaire.citation.volume13(9)pt_PT
person.familyNameVilela
person.familyNameGuedes
person.familyNameGomes
person.familyNamePrudêncio
person.familyNameAlmeida Vieira
person.givenNameCristiana
person.givenNameCarla
person.givenNameEduardo
person.givenNameCristina
person.givenNameMónica Andreia
person.identifier1888845
person.identifier776948
person.identifier1200571
person.identifier.ciencia-idD71B-7444-9438
person.identifier.ciencia-id2B11-8C00-A60D
person.identifier.ciencia-id7B13-B51D-97FF
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.ciencia-idA01E-9178-9B48
person.identifier.orcid0000-0003-3973-4768
person.identifier.orcid0000-0002-3277-7821
person.identifier.orcid0000-0003-3179-1741
person.identifier.orcid0000-0002-9920-936X
person.identifier.orcid0000-0002-8687-4811
person.identifier.ridD-3704-2017
person.identifier.scopus-author-id57447314300
person.identifier.scopus-author-id55931679600
person.identifier.scopus-author-id6508057930
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoveryb8be5870-5005-4956-8d55-262ccb7ccc82

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