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Risk of children’s dermal exposure to Galaxolide through personal care products

2015Journal article Open access
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dc.contributor.authorCorreia, Patrícia
dc.contributor.authorCruz, Agostinho
dc.contributor.authorSantos, Lúcia
dc.contributor.authorAlves, Arminda
dc.date.accessioned2019-05-20T14:51:56Z
dc.date.available2019-05-20T14:51:56Z
dc.date.issued2015
dc.description.abstractGalaxolide is the most used fragrance since the early 1990s, and it has been largely detected in environmental and biological matrices. This polycyclic musk is present in almost all of our daily products, so the risk of human exposure is substantial, as it had been proved by its detection in human tissues and fluids. Due to the lack of information about the concentrations found in consumer products, monitoring data is needed for exposure assessment purposes. Dermal contact, mostly by personal care products, seems to be the major route of human exposure to galaxolide, and, due to the immaturity of young children’s skin, exposure consequences can be worse in this population. The main objective of this study was to evaluate galaxolide levels in personal care products used by children of Oporto (Portugal), aged 0–5 years, and relate it with consumer habits. Consumer patterns were obtained through 250 questionnaires to caregivers of Oporto children. The 79 most used products were extracted by a dispersive solid phase extraction methodology known as QuEChERS and galaxolide was determined by High Performance Liquid Chromatography (HPLC) with fluorescence detection. The concentrations ranged between 0.001 ± 0.001 mg·kg−1, on a baby wipe, and 300.480 ± 8.819 mg·kg−1, on glycerin soap, which may correspond to an estimated daily dermal exposure of 277.10 ± 0.02 µg·day−1 on the population of Oporto children. This value is in the range of the results observed for adults, although no information of toxicological risk for children is available.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCorreia, P. C. dos S., Cruz, A., Santos, L., & Alves, A. (2015). Risk of Children’s Dermal Exposure to Galaxolide through Personal Care Products. Cosmetics, 2(2), 93–109. https://doi.org/10.3390/cosmetics2020093
dc.identifier.doi10.3390/cosmetics2020093pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/13755
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationNORTE-07-0124-FEDER-000025-RL2_Environment&Healthpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2079-9284/2/2/93pt_PT
dc.subjectDermal exposure riskpt_PT
dc.subjectChildrenpt_PT
dc.subjectGalaxolidept_PT
dc.subjectPersonal care productspt_PT
dc.subjectHPLC-fluorescencept_PT
dc.subjectQuEChERSpt_PT
dc.titleRisk of children’s dermal exposure to Galaxolide through personal care productspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FEQB%2FUI0511%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F70945%2F2010/PT
oaire.citation.endPage109pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage93pt_PT
oaire.citation.titleCosmeticspt_PT
oaire.citation.volume2pt_PT
oaire.fundingStreamCOMPETE
oaire.fundingStreamSFRH
person.familyNameCorreia
person.familyNameCruz
person.givenNamePatrícia Carla dos Santos Correia
person.givenNameAgostinho
person.identifier.ciencia-id221F-5A5F-BFC9
person.identifier.orcid0000-0001-7869-7977
person.identifier.orcid0000-0002-1157-8196
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationd7ec3c5d-b3e0-4e34-8e24-4d1588876120
relation.isAuthorOfPublication.latestForDiscoveryd7ec3c5d-b3e0-4e34-8e24-4d1588876120
relation.isProjectOfPublication3bf6d8a7-7fd1-4ff2-9f42-48b996731fa7
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