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Standardization of optical coherence tomography angiography imaging biomarkers in diabetic retinal disease

2021-07-30Journal article Open access
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dc.contributor.authorVujosevica, Stela
dc.contributor.authorCunha-Vaz, José
dc.contributor.authorFigueira, João
dc.contributor.authorLöwensteind, Anat
dc.contributor.authorMidena, Edoardo
dc.contributor.authorParravano, Mariacristina
dc.contributor.authorScanlon, Peter Henry
dc.contributor.authorSimó, Rafael
dc.contributor.authorHernández, Cristina
dc.contributor.authorMadeira, Maria H.
dc.contributor.authorMarques, Inês P.
dc.contributor.authorMartinho, António C.-V.
dc.contributor.authorSantos, Ana Rita
dc.contributor.authorSimó-Servat, Olga
dc.contributor.authorSalongcayk, Recivall P.
dc.contributor.authorZurd, Dinah
dc.contributor.authorPeto, Tunde
dc.date.accessioned2022-04-28T12:18:24Z
dc.date.available2022-04-28T12:18:24Z
dc.date.issued2021-07-30
dc.description.abstractOptical coherence tomography Angiography (OCT-A) represents a revolution in the noninvasive evaluation of retinal and choroidal circulation especially in detecting early clinical signs of diabetic retinal disease (DRD). With appropriate use, OCT-A characteristics and measurements have the potential to become new imaging biomarkers in managing and treating DRD. Major challenges include (a) provision of standardized outputs from different OCT-A instruments providing standardized terminology to correctly interpret data; (b) the presence of artifacts; (c) the absence of standardized grading or interpretation method in the evaluation of DRD, similar to that already established in fundus photography; and (d) establishing how OCT-A might be able to provide surrogate markers to demonstrate blood retinal barrier breakdown and vascular leakage, commonly associated with DRD. In fact, OCT-A guidelines for DRD are still evolving. The outputs of quantitative OCT-A data offer a unique opportunity to develop tools based on artificial intelligence to assist the clinicians in diagnosing, monitoring, and managing patients with diabetes. In addition, OCT-A has the potential to become a useful tool for the evaluation of cardiovascular diseases and different neurological diseases including cognitive impairment. This article written by the members of Diabetic Retinopathy expert committee of the European Vision Clinical Research network will review the available evidence on the use of OCT-A as an imaging biomarker in DRD and discuss the limits and the current application as well as future developments for its use in both clinical practice and research trials of DRD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVujosevic, S., Cunha-Vaz, J., Figueira, J., Löwenstein, A., Midena, E., Parravano, M., Scanlon, P. H., Simó, R., Hernández, C., Madeira, M. H., Marques, I. P., C.-V. Martinho, A., Santos, A. R., Simó-Servat, O., Salongcay, R. P., Zur, D., & Peto, T. (2021). Standardization of Optical Coherence Tomography Angiography Imaging Biomarkers in Diabetic Retinal Disease. Ophthalmic Research, 64(6), 871-887. https://doi.org/10.1159/000518620pt_PT
dc.identifier.doi10.1159/000518620pt_PT
dc.identifier.eissn1423-0259
dc.identifier.issn0030-3747
dc.identifier.urihttp://hdl.handle.net/10400.22/20418
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherKargerpt_PT
dc.relation.publisherversionhttps://www.karger.com/Article/FullText/518620pt_PT
dc.subjectOCT angiographypt_PT
dc.subjectDiabetic retinal diseasept_PT
dc.subjectImaging biomarkerspt_PT
dc.subjectStandardization of terminologypt_PT
dc.titleStandardization of optical coherence tomography angiography imaging biomarkers in diabetic retinal diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage887pt_PT
oaire.citation.startPage871pt_PT
oaire.citation.titleOphthalmic Researchpt_PT
oaire.citation.volume64pt_PT
person.familyNameB M Santos
person.givenNameAna Rita
person.identifier.ciencia-id291A-15C5-9C96
person.identifier.orcid0000-0003-3761-3292
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcf304315-48a2-4bae-a1d5-61a4c8e45274
relation.isAuthorOfPublication.latestForDiscoverycf304315-48a2-4bae-a1d5-61a4c8e45274

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