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Square-wave adsorptive-stripping voltammetric detection in the quality control of fluoxetine
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Orientador(es)
Resumo(s)
Electroanalytical methods based on square-wave adsorptive-stripping voltammetry
(SWAdSV) and flow-injection analysis with square-wave adsorptive-stripping
voltammetric detection (FIA-SWAdSV) were developed for the determination of fluoxetine
(FXT). The methods were based on the reduction of FXT at a mercury drop
electrode at -1.2 V versus Ag/AgCl, in a phosphate buffer of pH 12.0, and on the possibility
of accumulating the compound at the electrode surface. The SWAdSV method was
successfully applied in the quantification of FXT in pharmaceutical products, human
serum samples, and in drug dissolution studies. Because the presence of dissolved oxygen did not interfere significantly with the analysis, it was possible to quantify FXT in
several pharmaceutical products using FIA-SWAdSV. This method enables analysis of
up to 120 samples per hour at reduced costs.
Descrição
Palavras-chave
Fluoxetine Square-wave adsorptive-stripping voltammetry Flow-injection analysis Electrochemical detection Drug dissolution
Contexto Educativo
Citação
Editora
Taylor & Francis