Repository logo
 
Publication

Regeneration in the Podarcis bocagei model organism: a comprehensive immune-/histochemical analysis of the tail

2019-06-13Journal article Restricted access
Simple item page
dc.contributor.authorLuís, Carla
dc.contributor.authorRodrigues, llda
dc.contributor.authorGuerreiro, Susana G.
dc.contributor.authorFernandes, Rúben
dc.contributor.authorSoares, Raquel
dc.date.accessioned2022-04-08T13:16:36Z
dc.date.available2022-04-08T13:16:36Z
dc.date.issued2019-06-13
dc.description.abstractRegeneration is the process of regrowth of an injured/missing tissue/organ from the residual tissue. One outstanding example is the regeneration of tail in lizards in which they can completely regenerate without the formation of scaring or fibrotic tissue. This study presents an analysis of the main differences between a mature regenerated tail and the original tail of the lizard Podarcis bocagei by comparing histological biomarkers for support structures, morphology and pigmentation, vasculature and energy storage. Matured regenerated and original tails were studied with different histological staining’s and immunohistochemistry to highlight the various tissue components. We found differences in the morphological features scalation pattern and pigmentation, as well as in the support structures: muscle organization, collagen and calcification. Vasculature was remodeled. Energy storage was restored with regeneration maintaining therefore the main metabolic function. We demonstrate that the regenerated tail does not lose its main functions like locomotion and energy metabolism. The present findings may open a new window of research with implications in regenerative medicine.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLuís, C., Rodrigues, I., Guerreiro, S. G., Fernandes, R., & Soares, R. (2019). Regeneration in the Podarcis bocagei model organism: a comprehensive immune-/histochemical analysis of the tail. Zoomorphology, 138(3), 399-407. https://doi.org/10.1007/s00435-019-00452-6pt_PT
dc.identifier.doi10.1007/s00435-019-00452-6pt_PT
dc.identifier.eissn1432-234X
dc.identifier.issn0720-213X
dc.identifier.urihttp://hdl.handle.net/10400.22/20345
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Linkpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00435-019-00452-6pt_PT
dc.subjectTail regenerationpt_PT
dc.subjectHistologypt_PT
dc.subjectLizardspt_PT
dc.subjectPodarcis bocageipt_PT
dc.subjectRegenerative medicinept_PT
dc.titleRegeneration in the Podarcis bocagei model organism: a comprehensive immune-/histochemical analysis of the tailpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage407pt_PT
oaire.citation.startPage399pt_PT
oaire.citation.titleZoomorphology pt_PT
oaire.citation.volume138pt_PT
person.familyNameLuís
person.familyNameFernandes
person.givenNameCarla
person.givenNameRúben
person.identifier635792
person.identifier.ciencia-id351E-8683-D4AF
person.identifier.ciencia-id0D1F-4090-E82A
person.identifier.orcid0000-0002-5292-6337
person.identifier.orcid0000-0001-8933-3984
person.identifier.scopus-author-id57640135700
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9c59795c-c6e6-463b-995c-94bd321071f1
relation.isAuthorOfPublication9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4
relation.isAuthorOfPublication.latestForDiscovery9c59795c-c6e6-463b-995c-94bd321071f1

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ART_Carla Luís.pdf
Size:
4.07 MB
Format:
Adobe Portable Document Format
Download

Collections

ESS - GAS - Artigos
ESS - CQB - Artigos