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Microaneurysm turnover in mild non-proliferative diabetic retinopathy is associated with progression and development of vision-threatening complications: a 5-year longitudinal study

2021-05-15Journal article Open access
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dc.contributor.authorSantos, Ana Rita
dc.contributor.authorMendes, Luís
dc.contributor.authorMadeira, Maria Helena
dc.contributor.authorMarques, Inês P.
dc.contributor.authorTavares, Diana
dc.contributor.authorFigueira, João
dc.contributor.authorLobo, Conceição
dc.contributor.authorCunha-Vaz, José
dc.date.accessioned2021-07-06T11:00:08Z
dc.date.available2021-07-06T11:00:08Z
dc.date.issued2021-05-15
dc.description.abstractAnalysis of retinal microaneurysm turnover (MAT) has been previously shown to contribute to the identification of eyes at risk of developing clinically significant complications associated with diabetic retinopathy (DR). We propose to further characterize MAT as a predictive biomarker of DR progression and development of vision-threatening complications. Methods: 212 individuals with type 2 diabetes (T2D; ETDRS grades 20 and 35) were evaluated annually in a 5-year prospective, longitudinal study, by color fundus photography and optical coherence tomography. Endpoints were diabetic macular edema (DME) or proliferative retinopathy (PDR). MAT analysis included determination of MA formation and disappearance rates, automatically assessed using the RetMarkerDR®. Retinopathy severity progression was evaluated using step increases in ETDRS severity levels. Results: Of the 212 individuals, 172 completed the 5-year follow-up study or developed an endpoint (n = 27). MAT calculated at 1 year showed a significant difference between groups of endpoint developments (p = 0.018), particularly MA disappearance rate (p = 0.007). MAT also showed a significant difference between eyes with different ETDRS severity progression in the 5-year period (p = 0.035). MAT is an indicator of the development of DME and/or PDR as well as of DR severity progression in T2D individuals with mild retinopathy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, A. R., Mendes, L., Madeira, M. H., Marques, I. P., Tavares, D., Figueira, J., Lobo, C., & Cunha-Vaz, J. (2021). Microaneurysm Turnover in Mild Non-Proliferative Diabetic Retinopathy is Associated with Progression and Development of Vision-Threatening Complications: A 5-Year Longitudinal Study. Journal of Clinical Medicine, 10(10), 2142. https://www.mdpi.com/2077-0383/10/10/2142pt_PT
dc.identifier.doi10.3390/jcm10102142pt_PT
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/10400.22/18086
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/10/10/2142pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMicroaneurysmpt_PT
dc.subjectDiabetic retinopathypt_PT
dc.subjectSeverity progressionpt_PT
dc.subjectBiomarkerpt_PT
dc.titleMicroaneurysm turnover in mild non-proliferative diabetic retinopathy is associated with progression and development of vision-threatening complications: a 5-year longitudinal studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage8pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Clinical Medicinept_PT
oaire.citation.volume10pt_PT
person.familyNameB M Santos
person.givenNameAna Rita
person.identifier.ciencia-id291A-15C5-9C96
person.identifier.orcid0000-0003-3761-3292
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcf304315-48a2-4bae-a1d5-61a4c8e45274
relation.isAuthorOfPublication.latestForDiscoverycf304315-48a2-4bae-a1d5-61a4c8e45274

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