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Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder

2015Journal article Open access
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dc.contributor.authorNeto, Susana
dc.contributor.authorQuintela Vieira, Ana Filipa
dc.contributor.authorMontezuma, Diana
dc.contributor.authorCosta, Natália R.
dc.contributor.authorAntunes, Luís
dc.contributor.authorBaptista, Tiago
dc.contributor.authorOliveira, Ana Isabel
dc.contributor.authorPinho dos Santos Graça, Maria Inês
dc.contributor.authorRodrigues, Ângelo
dc.contributor.authorMagalhães, José S.
dc.contributor.authorOliveira, Jorge
dc.contributor.authorHenrique, Rui
dc.contributor.authorJerónimo, Carmen
dc.date.accessioned2019-01-30T18:06:23Z
dc.date.available2019-01-30T18:06:23Z
dc.date.issued2015
dc.description.abstractDeregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 levels were associated with improved patient survival. SiRNA experiments showed decrease cell viability and motility, and increased apoptosis. We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJunqueira-Neto, S., Vieira, F.Q., Montezuma, D., Costa, N.R., Antunes, L., Baptista, T., Oliveira, A.I., Graça, I., Rodrigues, Â., Magalhães, J.S., Oliveira, J., Henrique, R. and Jerónimo, C. (2015), Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder. Mol. Carcinog., 54: 523-531. https://doi.org/10.1002/mc.22117
dc.identifier.doi10.1002/mc.22117pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/12800
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/epdf/10.1002/mc.22117pt_PT
dc.subjectUrinary Bladderpt_PT
dc.subjectAgedpt_PT
dc.subjectRNApt_PT
dc.subjectBladder Neoplasmspt_PT
dc.subjectBladder Neoplasmspt_PT
dc.titlePhenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladderpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage531pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage523pt_PT
oaire.citation.titleMolecular Carcinogenesispt_PT
oaire.citation.volume54pt_PT
person.familyNameQuintela Vieira
person.familyNameLopes Botelho Antunes
person.familyNameOliveira
person.familyNamePinho dos Santos Graça
person.givenNameAna Filipa
person.givenNameLuís Jorge
person.givenNameAna Isabel
person.givenNameMaria Inês
person.identifier.ciencia-id191A-2C57-EDA4
person.identifier.orcid0000-0003-0130-7664
person.identifier.orcid0000-0002-3098-0711
person.identifier.orcid0000-0002-3160-6596
person.identifier.orcid0000-0003-1383-4242
person.identifier.scopus-author-id6505981373
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication47123d10-a0ed-47cc-a751-721489a13446
relation.isAuthorOfPublication91058263-4be5-4bec-ae59-fa0015ef529c
relation.isAuthorOfPublicationb38c382c-5355-4b8e-aae0-45af3aa1dc8e
relation.isAuthorOfPublication8316e6ce-cc0a-41e6-90ab-910c93868670
relation.isAuthorOfPublication.latestForDiscovery8316e6ce-cc0a-41e6-90ab-910c93868670

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