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Comparative Study of Subcortical Atrophy in Patients with Frontotemporal Dementia and Dementia with Extrapyramidal Signs

2015Journal article Restricted access
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dc.contributor.authorCaixeta, Leonardo
dc.contributor.authorVieira, Renata Teles
dc.contributor.authorPaes, Flávia
dc.contributor.authorCarta, Mauro Giovanni
dc.contributor.authorNardi, Antonio Egidio
dc.contributor.authorArias-Carrión, Oscar
dc.contributor.authorRocha, Nuno
dc.contributor.authorBudde, Henning
dc.contributor.authorMachado, Sergio
dc.date.accessioned2019-07-15T16:59:27Z
dc.date.available2019-07-15T16:59:27Z
dc.date.issued2015
dc.description.abstractTo investigate the severity of subcortical atrophy in frontotemporal dementia (FTD) without extrapyramidal symptoms (EPS) and dementia with EPS. In addition, we aim to verify if there is correlation between demographic and clinical characteristics and subcortical atrophy in the groups. Methodology : The sample was composed of 21 patients with dementia and EPS as well as 19 patients with FTD without EPS. A linear assessment was conducted in order to identify the degree of subcortical atrophy (i.e., bifrontal index - BFI) using MRI. Moreover, the Mini-Mental State Examination (MMSE), Pfeffer Functional Activities Questionnaire (FAQ) and the Clinical Dementia Rating (CDR) were used to investigate clinical aspects. Results : It was verified that patients with dementia and EPS was older than the patients with FTD (p=0.01). The severity of cognitive deficits was associated with BFI, as well as the dementia severity in the EPS group. Conclusion : FTD group presented mean BFI scores above the cutoff for normal elderly population, indicating the presence of subcortical atrophy in this group. Mean BFI was higher (although not statistically significant) in FTD group than in dementia with EPS, which can suggest at least that subcortical pathology in FTD may be as important as in the dementia with EPS group. Subcortical atrophy is a good biological marker for cognitive deterioration in FTD and in dementia with EPS.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2174/1745017901511010125pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14378
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBentham Openpt_PT
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391205/pt_PT
dc.subjectBifrontal indexpt_PT
dc.subjectExtrapyramidal signspt_PT
dc.subjectFrontotemporal dementiapt_PT
dc.subjectStructural neuroimagingpt_PT
dc.subjectSubcortical atrophypt_PT
dc.titleComparative Study of Subcortical Atrophy in Patients with Frontotemporal Dementia and Dementia with Extrapyramidal Signspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage129pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage125pt_PT
oaire.citation.titleClinical Practice and Epidemiology in Mental Health :: Cp && Emhpt_PT
oaire.citation.volume11pt_PT
person.familyNameRocha
person.givenNameNuno
person.identifier192266
person.identifier.ciencia-idAE16-A494-5F8B
person.identifier.orcid0000-0002-3139-2786
person.identifier.ridM-9821-2013
person.identifier.scopus-author-id32867975300
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9e940914-601a-4978-8d5b-74e5ade7ada7
relation.isAuthorOfPublication.latestForDiscovery9e940914-601a-4978-8d5b-74e5ade7ada7

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