Publication
Development and Optimization of a Topical Formulation with Castanea sativa Shells Extract Based on the Concept “Quality by Design”
| dc.contributor.author | Oliveira, Nágilla | |
| dc.contributor.author | Cádiz-Gurrea, María de La Luz | |
| dc.contributor.author | Silva, Ana Margarida | |
| dc.contributor.author | Macedo, Catarina | |
| dc.contributor.author | Rodrigues, Francisca | |
| dc.contributor.author | Costa, Paulo | |
| dc.date.accessioned | 2023-01-31T10:21:08Z | |
| dc.date.available | 2023-01-31T10:21:08Z | |
| dc.date.issued | 2021-12-23 | |
| dc.description.abstract | The proposed study aims to develop and optimize a topical formulation with Castanea sativa shells extract considering the concept of Quality by Design, focusing on a planned development that consider the vulnerabilities of the entire process through risk analysis tools and design of experiments (DoE). A Box–Behnken design with three factors and three levels was used as a statistical tool for the execution of the DoE and the analysis of the response surface methodology responses. The independent variables studied were the quantity of sodium lauryl sulfate (%) (X1), beeswax (%) (X2) and macadamia oil (%) (X3); the dependent variables were pH (Y1), viscosity (Y2) and adhesiveness (Y3). According to the mathematical model, the optimal formulation contains 0.93% of sodium lauryl sulfate, 5.00% of beeswax and 10.00% of macadamia oil. The optimal formulation with the extract was prepared and characterized over the time, regarding organoleptic and technological characteristics, allowing conclusions to be reached regarding its stability. The formulation presented a pleasant odor and was light brown in color, it also demonstrated pseudoplastic-thixotropic behavior and a small reduction in the formulation consistency after 30 days of storage. This study demonstrated the efficiency of the Quality by Design methodology to understand the product variability, supporting that this approach favors a better understanding of the whole process and enables to design a robust development stage, reducing costs and generating high-quality products | pt_PT |
| dc.description.sponsorship | This research was supported by project PTDC/ASP-AGR/29277/2017—Castanea sativa shells as a new source of active ingredients for functional food and cosmetic applications: a sustainable approach, financially supported by national funds by FCT/MCTES and co-supported by Fundo Europeu de Desenvolvimento Regional (FEDER) throughout COMPETE 2020—Programa Operacional Competitividade e Internacionalização (POCI-01-0145-FEDER-029277). The authors are thankful to Sortegel for the samples. Ana Margarida Silva is thankful for her Ph.D. grant (SFRH/BD/144994/2019) financed by POPH-QREN and subsidized by the European Science Foundation and Ministério da Ciência, Tecnologia e Ensino Superior. Francisca Rodrigues (CEECIND/01886/2020) is thankful for her contract financed by FCT/MCTES—CEEC Individual Program Contract. This work was also financed by national funds from FCT - Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDB/50006/2020. This work was also supported by national funds from FCT - Fundação para a Ciência e a Tecnologia, I.P., in the scope of the projects UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences – UCIBIO and project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy - i4HB | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.3390/su14010129 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.22/22022 | |
| dc.language.iso | eng | pt_PT |
| dc.publisher | MDPI | pt_PT |
| dc.relation | POCI-01-0145-FEDER-029277 | pt_PT |
| dc.relation | Castanea sativa shells as a new source of active ingredients for Functional Food and Cosmetic applications: a sustainable approach | |
| dc.relation | From soil to skin: Eco-friendly extract from kiwiberry leaves for prevention of skin aging process | |
| dc.relation | Applied Molecular Biosciences Unit | |
| dc.relation | Applied Molecular Biosciences Unit | |
| dc.relation.publisherversion | https://www.mdpi.com/2071-1050/14/1/129 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
| dc.subject | Castanea sativa shells | pt_PT |
| dc.subject | Design of experiments | pt_PT |
| dc.subject | Response surface methodology | pt_PT |
| dc.subject | Risk assessment | pt_PT |
| dc.subject | Cosmetics | pt_PT |
| dc.title | Development and Optimization of a Topical Formulation with Castanea sativa Shells Extract Based on the Concept “Quality by Design” | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Castanea sativa shells as a new source of active ingredients for Functional Food and Cosmetic applications: a sustainable approach | |
| oaire.awardTitle | From soil to skin: Eco-friendly extract from kiwiberry leaves for prevention of skin aging process | |
| oaire.awardTitle | Applied Molecular Biosciences Unit | |
| oaire.awardTitle | Applied Molecular Biosciences Unit | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FASP-AGR%2F29277%2F2017/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F144994%2F2019/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT | |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 129 | pt_PT |
| oaire.citation.title | Sustainability | pt_PT |
| oaire.citation.volume | 14 | pt_PT |
| oaire.fundingStream | 9471 - RIDTI | |
| oaire.fundingStream | POR_NORTE | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| person.familyName | Cádiz-Gurrea | |
| person.familyName | Silva | |
| person.familyName | Pinheiro Macedo | |
| person.familyName | Pinto Lisboa Martins Rodrigues Sarmento | |
| person.givenName | María de la Luz | |
| person.givenName | Ana Margarida | |
| person.givenName | Catarina | |
| person.givenName | Francisca | |
| person.identifier | 1203297 | |
| person.identifier | 1552042 | |
| person.identifier.ciencia-id | BC1F-EAC8-C092 | |
| person.identifier.ciencia-id | 5C16-8C22-EF1E | |
| person.identifier.ciencia-id | 6F19-BED8-EEC7 | |
| person.identifier.ciencia-id | 4F19-3D98-2CBA | |
| person.identifier.orcid | 0000-0002-2613-4889 | |
| person.identifier.orcid | 0000-0002-1823-9816 | |
| person.identifier.orcid | 0000-0002-6108-8582 | |
| person.identifier.orcid | 0000-0001-8803-0041 | |
| person.identifier.rid | K-9398-2014 | |
| person.identifier.scopus-author-id | 55454378200 | |
| person.identifier.scopus-author-id | 57203495060 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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