Publication
Validation of CINtec® PLUS cytology kit in the diagnosis of persistent HPV infections - Cohort study in the Portuguese population
| dc.contributor.author | Abreu, Ângela | |
| dc.contributor.author | Silva, Regina | |
| dc.contributor.author | Fernandes, Sílvia | |
| dc.date.accessioned | 2021-07-23T10:34:19Z | |
| dc.date.available | 2021-07-23T10:34:19Z | |
| dc.date.issued | 2021-05-10 | |
| dc.description.abstract | The use of the CINtec® PLUS Cytology Kit as a complementary method of diagnosis is intended to contribute to a risk assessment of CIN II+ cervical lesions development, thus avoiding unnecessary colposcopy in negative cases. This method has proved to be effective in the follow-up of cervical lesions, although there is need for consistency in the approach of equivocal or negative cytological results, with persistent positive High-Risk Human Papillomavirus (HR-HPV) test. Aims: The present study intends to retrospectively evaluate the capacity of the CINtec® to add information to the clinical practice within the screening and follow-up of cervical lesions. Additionally, this study intends to define criteria for CINtec® referral in order to maximize its utilization in the Portuguese context. Materials and Methods: For this purpose, 225 cases with CINtec® PLUS Cytology Kit and histology results were used, and data were analysed and compared according to the cytology and HR-HPV molecular test results. Results: The data of this study show that CINtec® PLUS Cytology Kit is a valid test for the diagnosis of persistent HPV lesions (p = 0.0005), with excellent sensitivity and reliable values of specificity. Relevant patient groups to apply the kit are in agreement with the manufacturer recommendations: women with ASC-US/LSIL result and NILM cytology with HPV-positive test, essentially over 30 years old. Conclusions: Although clinical data and previous cytological information must help guiding, authors considered that CINtec® is a really valid test for the prognosis of persistent HPV infections in the female population. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Abreu ÂL, Silva RA, Fernandes S. Validation of CINtec® PLUS cytology kit in the diagnosis of persistent HPV infections - Cohort study in the Portuguese population. J Cytol [serial online] 2021 [cited 2021 Jul 21];38:94-100. Available from: https://www.jcytol.org/text.asp?2021/38/2/94/315771 | pt_PT |
| dc.identifier.doi | 10.4103/JOC.JOC_173_20 | pt_PT |
| dc.identifier.issn | 0974-5165 | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/18164 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Wolters Kluwer; MedKnow | pt_PT |
| dc.relation.publisherversion | https://journals.lww.com/jocy/fulltext/2021/38020/validation_of_cintec__plus_cytology_kit_in_the.7.aspx | pt_PT |
| dc.subject | Cervical cytology | pt_PT |
| dc.subject | Cervical intraepithelial neoplasia | pt_PT |
| dc.subject | High grade | pt_PT |
| dc.subject | Immunocytochemistry | pt_PT |
| dc.subject | Triage | pt_PT |
| dc.title | Validation of CINtec® PLUS cytology kit in the diagnosis of persistent HPV infections - Cohort study in the Portuguese population | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 7 | pt_PT |
| oaire.citation.startPage | 1 | pt_PT |
| oaire.citation.title | Journal of Cytology | pt_PT |
| oaire.citation.volume | 38 | pt_PT |
| person.familyName | Silva | |
| person.familyName | Fernandes | |
| person.givenName | Regina | |
| person.givenName | Sílvia | |
| person.identifier.ciencia-id | 871B-D071-507D | |
| person.identifier.ciencia-id | FB1A-1376-32B8 | |
| person.identifier.orcid | 0000-0002-8373-1217 | |
| person.identifier.orcid | 0000-0003-2031-0658 | |
| person.identifier.scopus-author-id | 57195931190 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 60471846-7876-49e1-b405-6ffe770795ae | |
| relation.isAuthorOfPublication | a15c298e-1ac3-4aac-855c-ec6acbc30e25 | |
| relation.isAuthorOfPublication.latestForDiscovery | a15c298e-1ac3-4aac-855c-ec6acbc30e25 |