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Design of an Emulgel for Psoriasis Focused on Patient Preferences

2022Journal article Open access
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dc.contributor.authorOliveira, Rita Sanches
dc.contributor.authorda Silva, Diva Ferraz
dc.contributor.authorMota, Sandra
dc.contributor.authorGarrido, Jorge
dc.contributor.authorGarrido, E. Manuela
dc.contributor.authorLobo, José Manuel Sousa
dc.contributor.authorAlmeida, Isabel Filipa
dc.date.accessioned2023-02-14T16:50:34Z
dc.date.available2023-02-14T16:50:34Z
dc.date.issued2022
dc.description.abstractAdherence to topical treatments is low and is known to be influenced by the vehicle properties. Betamethasone dipropionate (BD) is an anti-inflammatory steroid, used in psoriasis treatment in the form of an ointment, cream, or solution. The aim of this work was to develop a new vehicle for BD, focusing on the preferences of patients with psoriasis as a strategy to improve treatment adherence. Two vehicles with an aqueous external phase were explored: an emulgel and a hydrogel based on a cyclodextrin inclusion complex used to improve the aqueous solubility of BD. Since BD solubilization was not fully achieved in the hydrogel, only the emulgel was selected for further characterization. This new vehicle (emulgel) is characterized by its white, shiny appearance and good spreading properties. In comparison with petrolatum, a lower residue, higher evaporation rate, lower stickiness, and reduced ability to stain polyester fabric were observed. This vehicle also showed shear thinning behavior. The impact of this new vehicle on adherence to topical treatments should be further confirmed in clinical settings.pt_PT
dc.description.sponsorshipThis work was financed by national funds under the project 47239-Cork2Cosmetic (NORTE-01-0247-FEDER-047239). S. Mota acknowledges the research fellowship (NORTE-01-0247-FEDER-047239), fully supported by national funding from project 47239-Cork2Cosmetic (NORTE-01-0247-FEDER-047239). This work was supported by national funds from FCT-Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020, UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences-UCIBIO. The projects UIDB/00081/2020 and I LA/P/0056/2020 were funded by FCT/MCTES (PIDDAC).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/app12073260pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/22284
dc.language.isoengpt_PT
dc.publisherMDPIpt_PT
dc.relationNORTE-01-0247-FEDER-047239pt_PT
dc.relation47239-Cork2Cosmeticpt_PT
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationChemistry Research Unit of University of Porto
dc.relation.publisherversionhttps://www.mdpi.com/2076-3417/12/7/3260pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectTopical vehiclespt_PT
dc.subjectHydrogelpt_PT
dc.subjectEmulgelpt_PT
dc.subjectPsoriasispt_PT
dc.subjectCyclodextrinspt_PT
dc.subjectPatient-centric designpt_PT
dc.subjectMedication adherencept_PT
dc.titleDesign of an Emulgel for Psoriasis Focused on Patient Preferencespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleChemistry Research Unit of University of Porto
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00081%2F2020/PT
oaire.citation.issue7pt_PT
oaire.citation.startPage3260pt_PT
oaire.citation.titleApplied Sciencespt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGarrido
person.familyNameGarrido
person.givenNameJorge
person.givenNameE. Manuela
person.identifier.ciencia-id0219-E083-0653
person.identifier.orcid0000-0001-8981-231X
person.identifier.orcid0000-0001-9050-6168
person.identifier.scopus-author-id7202779733
person.identifier.scopus-author-id7004992709
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoveryfd4663b7-32c1-4e18-a389-92a1647f1520
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