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Colorimetric Paper-Based Sensors against Cancer Biomarkers

2022Journal article Open access
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dc.contributor.authorCarneiro, Mariana
dc.contributor.authorRodrigues, R. V.
dc.contributor.authorMoreira, Felismina
dc.contributor.authorFerreira Sales, Maria Goreti
dc.date.accessioned2023-01-25T16:26:51Z
dc.date.available2023-01-25T16:26:51Z
dc.date.issued2022
dc.description.abstractCancer is a major cause of mortality and morbidity worldwide. Detection and quantification of cancer biomarkers plays a critical role in cancer early diagnosis, screening, and treatment. Clinicians, particularly in developing countries, deal with high costs and limited resources for diagnostic systems. Using low-cost substrates to develop sensor devices could be very helpful. The interest in paper-based sensors with colorimetric detection increased exponentially in the last decade as they meet the criteria for point-of-care (PoC) devices. Cellulose and different nanomaterials have been used as substrate and colorimetric probes, respectively, for these types of devices in their different designs as spot tests, lateral-flow assays, dipsticks, and microfluidic paper-based devices (μPADs), offering low-cost and disposable devices. However, the main challenge with these devices is their low sensitivity and lack of efficiency in performing quantitative measurements. This review includes an overview of the use of paper for the development of sensing devices focusing on colorimetric detection and their application to cancer biomarkers. We highlight recent works reporting the use of paper in the development of colorimetric sensors for cancer biomarkers, such as proteins, nucleic acids, and others. Finally, we discuss the main advantages of these types of devices and highlight their major pitfalls.pt_PT
dc.description.sponsorshipThis research was funded by Portuguese Foundation for Science and Technology (FCT), under the scope of the strategic funding of UIDB/04469/2020 unit and through Mariana Carneiro PhD grant reference SFRH/BD/131959/2017.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/s22093221pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/21868
dc.language.isoengpt_PT
dc.publisherMDPIpt_PT
dc.relationCentre of Biological Engineering of the University of Minho
dc.relationTest-strips for monitoring cancer biomarkers in point-of-care
dc.relation.publisherversionhttps://www.mdpi.com/1424-8220/22/9/3221pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPaper-based devicespt_PT
dc.subjectColorimetric detectionpt_PT
dc.subjectCancer diagnosispt_PT
dc.titleColorimetric Paper-Based Sensors against Cancer Biomarkerspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre of Biological Engineering of the University of Minho
oaire.awardTitleTest-strips for monitoring cancer biomarkers in point-of-care
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04469%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F131959%2F2017/PT
oaire.citation.issue9pt_PT
oaire.citation.startPage3221pt_PT
oaire.citation.titleSensorspt_PT
oaire.citation.volume22pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
person.familyNameCarneiro
person.familyNameRodrigues
person.familyNameMoreira
person.familyNameFerreira Sales
person.givenNameMariana
person.givenNameRaul
person.givenNameFelismina
person.givenNameMaria Goreti
person.identifier1589429
person.identifier826970
person.identifier.ciencia-idC917-6A46-A270
person.identifier.ciencia-idE31F-1630-42BB
person.identifier.orcid0000-0002-1971-261X
person.identifier.orcid0000-0003-2462-9930
person.identifier.orcid0000-0003-4237-8952
person.identifier.orcid0000-0001-9936-7336
person.identifier.ridK-9199-2013
person.identifier.scopus-author-id23486193000
person.identifier.scopus-author-id7005174717
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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