Loading...
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 3.57 MB | Adobe PDF |
Authors
Abstract(s)
Pyrethroids are pesticides very used in agriculture, which tend to replace
organophosfate and carbamate insecticides. These pesticides have shown to exhibit
cardiotoxicity.
The aim of this study was to assess if cardiotoxicity is due to direct or indirect effects
(metabolites) of permethrin on hearts. There were studies 8 rats; three of them were
sacrificed after 24 of the end of treatment with permethrin and the other four were
sacrificed after 14 days of the end of treatment. Afterwards hearts and urines were
collected. The amounts of permethrin and its main metabolite (3-PBA) were
evaluated on hearts and urines of female rats which were treated with permethrin and
sacrificed the day after and 14 days after the treatment. Moreover has been
highlighted the difference of amount of permethrin and its metabolite between rats
sacrificed immediately at the end of treatment and those sacrificed after 14 days. The
study of permethrin was accomplished by liquid-liquid extraction and GC-ECD. The
evaluation of 3-PBA was performed by SPE procedure with 2-PBA as internal
standard and gas-chromatography GC-MS. The concentration of permethrin in hearts
is basically the same in 24h and 14 days. The 3-PBA concentration in urines
decreased 50 times from 24h to 14 days. In hearts the 3-PBA level also decrease but
only 2.24 times and a high variation of results were achieved in rats after 14 days.
Description
Keywords
Pesticides Permethrin Metabolites 3-phenoxybenzoic acid 2- phenoxybenzoic acid Chromatography GC-MS GC-ECD Extraction Derivatization Heart Urine