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Impact of walking on knee articular cartilage T2 values estimated with a dictionary-based approach - A pilot study

2024-10Journal article Open access
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dc.contributor.authorCoelho, José M.
dc.contributor.authorFernandes, T.T.
dc.contributor.authorAlves, Sandra Maria
dc.contributor.authorNunes, R.G.
dc.contributor.authorNogueira, Luísa
dc.contributor.authorOliveira, A.
dc.date.accessioned2024-12-09T15:03:41Z
dc.date.embargo2025-10
dc.date.issued2024-10
dc.description.abstractWalking is crucial for knee articular cartilage (KAC) health. Routine MRI sequences lack sensitivity for early cartilage changes, and the use of parametric T2 maps to study the effect of walking on KAC composition is limited. This study aimed to evaluate if quantitative T2 maps using an Echo Modulation Curve (EMC) matching algorithm can detect KAC T2 variations due to water content changes after walking. Seven asymptomatic volunteers (3 females, 4 males, mean age 28.3 years) without knee pathologies participated. Sagittal knee MRI scans were performed before and after a 9-min treadmill walk using a Modified Bruce protocol. T2-weighted Multi-Echo Spin-Echo KAC images were acquired at 3T. Tibiofemoral cartilage was segmented semi-automatically on three slices per knee, defining 39 KAC samples. Quantitative T2 maps were created using a dictionary-matching algorithm. Paired t-tests assessed exercise impact on KAC T2 values, independent t-tests compared group differences, and Friedman test with Bonferroni correction evaluated regional T2 changes. Walking increased KAC T2 values (mean difference (md) 0.61 ± 1.71 ms; p ¼ 0.016). Significant differences were observed in “normal” BMI group (md 0.69 ± 1.27 ms; p ¼ 0.021). Regional analysis revealed significant differences in medial femur in males (md 0.9 ± 2.1 ms; p ¼ 0.049) and lateral tibia in females (md 1.4 ± 2.5 ms; p ¼ 0.046). The medial tibia showed significant differences across sub-regions (p ¼ 0.026). Quantitative T2 maps using the EMC matching algorithm detected consistent changes in KAC T2 values after a short walking period. Implications for practice: EMC quantitative T2 maps effectively detected knee cartilage changes postwalking. This technique could improve cartilage hydration assessments, aiding early detection in atrisk patients. It also suggests potential for personalized monitoring and rehabilitation, advancing musculoskeletal imaging and non-invasive joint health monitoring.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCoelho, J. M., Fernandes, T. T., Alves, S. M., Nunes, R. G., Nogueira, L., & Oliveira, A. (2025). Impact of walking on knee articular cartilage T2 values estimated with a dictionary-based approach—A pilot study. Radiography, 31(1), 66–74. https://doi.org/10.1016/j.radi.2024.10.018pt_PT
dc.identifier.doi10.1016/j.radi.2024.10.018pt_PT
dc.identifier.eissn1532-2831
dc.identifier.issn1078-8174
dc.identifier.urihttp://hdl.handle.net/10400.22/26711
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationThis work received supported by Fundaç~ao para a Ci^encia e a Tecnologia (FCT), namely LARSyS funding (DOI: 10.54499/LA/P/ 0083/2020, 10.54499/UIDP/50009/2020, and 2020. 05080.BD).pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S107881742400316X?via%3Dihubpt_PT
dc.subjectWalkingpt_PT
dc.subjectArticular cartilagept_PT
dc.subjectKneept_PT
dc.subjectQuantitativept_PT
dc.subjectT2 mapspt_PT
dc.subjectMagnetic resonance imagingpt_PT
dc.subjectEMC matching algorithmpt_PT
dc.titleImpact of walking on knee articular cartilage T2 values estimated with a dictionary-based approach - A pilot studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage74pt_PT
oaire.citation.startPage66pt_PT
oaire.citation.titleRadiographypt_PT
oaire.citation.volume31 (1)pt_PT
person.familyNameCoelho
person.familyNameAlves
person.familyNameNogueira
person.givenNameJosé Manuel
person.givenNameSandra Maria
person.givenNameLuisa
person.identifier2571691
person.identifier.ciencia-id3C14-FF17-9C1B
person.identifier.ciencia-idCF1F-D1D5-6BC1
person.identifier.orcid0000-0003-2039-3289
person.identifier.orcid0000-0002-2318-7491
person.identifier.orcid0000-0002-1291-9490
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa873111e-2b73-4550-947d-8c0bed92751a
relation.isAuthorOfPublicationf91e1151-4aad-4af3-9fef-970548be5f0c
relation.isAuthorOfPublicationc2991b07-7696-4d2b-ad5d-863790e33130
relation.isAuthorOfPublication.latestForDiscoveryf91e1151-4aad-4af3-9fef-970548be5f0c

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