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Glucose diffusion in colorectal mucosa—a comparative study between normal and cancer tissues

2017-02-21Journal article Restricted access
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dc.contributor.authorCarvalho, Sónia
dc.contributor.authorGueiral, Nuno
dc.contributor.authorNogueira, Elisabete
dc.contributor.authorHenrique, Rui
dc.contributor.authorOliveira, Luís
dc.contributor.authorTuchin, Valery
dc.date.accessioned2017-03-03T11:59:45Z
dc.date.embargo2117
dc.date.issued2017-02-21
dc.description.abstractColorectal carcinoma is a major health concern worldwide and its high incidence and mortality require accurate screening methods. Following endoscopic examination, polyps must be removed for histopathological characterization. Aiming to contribute to the improvement of current endoscopy methods of colorectal carcinoma screening or even for future development of laser treatment procedures, we studied the diffusion properties of glucose and water in colorectal healthy and pathological mucosa. These parameters characterize the tissue dehydration and the refractive index matching mechanisms of optical clearing (OC). We used ex vivo tissues to measure the collimated transmittance spectra and thickness during treatments with OC solutions containing glucose in different concentrations. These time dependencies allowed for estimating the diffusion time and diffusion coefficient values of glucose and water in both types of tissues. The measured diffusion times for glucose in healthy and pathological mucosa samples were 299.2+/-4.7 s and 320.6+/-10.6 s for 40% and 35% glucose concentrations, respectively. Such a difference indicates a slower glucose diffusion in cancer tissues, which originate from their ability to trap far more glucose than healthy tissues. We have also found a higher free water content in cancerous tissue that is estimated as 64.4% instead of 59.4% for healthy mucosa.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGlucose diffusion in colorectal mucosa: a comparative study between normal and cancer tissues," J. Biomed. Opt. 22(9), 091506 (2017), doi: 10.1117/1.JBO.22.9.091506pt_PT
dc.identifier.doi10.1117/1.JBO.22.9.091506pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/9555
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociety of Photo-optical Instrumentation Engineerspt_PT
dc.relation.ispartofseriesJournal of Biomedical Optics;Vol.22, Issue 9
dc.relation.publisherversionhttp://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=2606413pt_PT
dc.subjectColorectal tissuept_PT
dc.subjectCancerpt_PT
dc.subjectFree and bound waterpt_PT
dc.subjectOptical clearingpt_PT
dc.subjectDiffusion coefficientpt_PT
dc.subjectTissue dehydrationpt_PT
dc.titleGlucose diffusion in colorectal mucosa—a comparative study between normal and cancer tissuespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUSApt_PT
oaire.citation.endPage091506-12pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage091506-1pt_PT
oaire.citation.titleJournal of Biomedical Opticspt_PT
oaire.citation.volume22pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT

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