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The relation between functional parameters, C-reactive protein and erythrocyte sedimentation rate in ankylosing spondylitis: a cross-sectional study

2022-01-12Journal article Open access
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dc.contributor.authorLopes, Sofia Manuela da Rocha
dc.contributor.authorDuarte, José Alberto Ramos
dc.contributor.authorSantos, Paula Clara
dc.contributor.authorMesquita, Cristina Teresa Torrão Carvalho
dc.date.accessioned2022-10-18T09:00:51Z
dc.date.available2022-10-18T09:00:51Z
dc.date.issued2022-01-12
dc.description.abstractAnkylosing spondylitis (AS) is a chronic inflammatory rheumatic disease characterised by inflammation of the spine and the sacroiliac joints and stiffness, which leads to a progressive decline in the quality of life of individuals. Bath indices are considered the principal functional outcome measure and Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP) are the most widely used biomarkers in AS to assess disease activity. To characterise individuals with AS and to examine the association between functional parameters and biomarkers. Thirty-one patients were recruited from the National Association of Ankylosing Spondylitis (ANEA) – Centre of northern region of Portugal, between February 2014 and June 2015, to be included in the present study. The Bath indices [Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Metrology Index (BASMI)], the Neck Disability Index (NDI), the Oswestry Disability Index (ODI) and laboratory parameters such as ESR and CRP were analysed. The participants’ mean age was 42.77 (±14.37) years, with 18 (58.1%) women and 13 (41.9%) men. The mean scores were 3.55 (BASDAI), 2.78 (BASFI) and 2.58 (BASMI). The final mean scores were 25.81± 18.36 (NDI) and 23.29±15.32 (ODI). We found a negative association between ESR and BASDAI (β=-0.038, p=0.025), and between ESR and BASFI (β=-0.044, p=0.013). As to CRP, there was no statistically significant association between Bath indices. This cross-sectional study in AS patients demonstrated that, on the one hand, this sample had a high education level, having been diagnosed with AS for more than 15 years, with a moderate disability and, on the other hand, with the adjustment of education level and years since diagnosis, there was an association between ESR and BASDAI and BASFI scores.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSofia Manuela da Rocha Lopes, José Alberto Ramos Duarte, Paula Clara Santos. The Relation Between Functional Parameters, C-Reactive Protein and Erythrocyte Sedimentation Rate in Ankylosing Spondylitis: A Cross-Sectional Study. Arch Rheum & Arthritis Res. 2(1): 2022. ARAR.MS.ID.000527.pt_PT
dc.identifier.doi10.33552/ARAR.2022.02.000527pt_PT
dc.identifier.issn2694-1724
dc.identifier.urihttp://hdl.handle.net/10400.22/20927
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherIris Publisherspt_PT
dc.relation.publisherversionhttps://irispublishers.com/arar/fulltext/the-relation-between-functional-parameters-c-reactive-protein-and-erythrocyte-sedimentation-rate.ID.000527.phppt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnkylosing spondylitispt_PT
dc.subjectFunctionalitypt_PT
dc.subjectBiomarkerspt_PT
dc.subjectInflammationpt_PT
dc.subjectPain pt_PT
dc.titleThe relation between functional parameters, C-reactive protein and erythrocyte sedimentation rate in ankylosing spondylitis: a cross-sectional studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage6pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleArchives of Rheumatology & Arthritis Researchpt_PT
person.familyNameLopes
person.familyNameSantos
person.familyNameCarvalho Mesquita
person.givenNameSofia
person.givenNamePaula Clara
person.givenNameCristina
person.identifier2641453
person.identifier.ciencia-id6E18-5E9B-9CA6
person.identifier.ciencia-id5C16-2441-F091
person.identifier.ciencia-id221C-ECA5-4EB4
person.identifier.orcid0000-0002-3306-7557
person.identifier.orcid0000-0003-3548-700X
person.identifier.orcid0000-0003-0830-9064
person.identifier.scopus-author-id57103538800
person.identifier.scopus-author-id35848786400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd28d4024-424a-4597-beb1-007500e8902b
relation.isAuthorOfPublication78bef72f-1c59-47e1-a79d-3e4f8e0d438d
relation.isAuthorOfPublicationb8eda95a-0cca-4eed-aed6-2cca990169d3
relation.isAuthorOfPublication.latestForDiscoveryb8eda95a-0cca-4eed-aed6-2cca990169d3

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