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Application of gold nanoparticles as radiosensitizer for metastatic prostate cancer cell lines

2023-02-18Journal article Open access
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dc.contributor.authorSoares, Sílvia
dc.contributor.authorFaria, Isabel
dc.contributor.authorAires, Fátima
dc.contributor.authorMonteiro, Armanda
dc.contributor.authorPinto, Gabriela
dc.contributor.authorSales, Maria Goreti
dc.contributor.authorCorrea-Duarte, Miguel A.
dc.contributor.authorGuerreiro, Susana G.
dc.contributor.authorFernandes, Rúben
dc.date.accessioned2024-03-18T15:58:55Z
dc.date.available2024-03-18T15:58:55Z
dc.date.issued2023-02-18
dc.description.abstractMore than 50% of all prostate cancer (PCa) patients are treated by radiotherapy (RT). Radioresistance and cancer recurrence are two consequences of the therapy and are related to dose heterogeneity and non-selectivity between normal and tumoral cells. Gold nanoparticles (AuNPs) could be used as potential radiosensitizers to overcome these therapeutic limitations of RT. This study assessed the biological interaction of different morphologies of AuNPs with ionizing radiation (IR) in PCa cells. To achieve that aim, three different amine-pegylated AuNPs were synthesized with distinct sizes and shapes (spherical, AuNPsp-PEG, star, AuNPst-PEG, and rods, AuNPr-PEG) and viability, injury and colony assays were used to analyze their biological effect on PCa cells (PC3, DU145, and LNCaP) when submitted to the accumulative fraction of RT. The combinatory effect of AuNPs with IR decreased cell viability and increased apoptosis compared to cells treated only with IR or untreated cells. Additionally, our results showed an increase in the sensitization enhancement ratio by cells treated with AuNPs and IR, and this effect is cell line dependent. Our findings support that the design of AuNPs modulated their cellular behavior and suggested that AuNPs could improve the RT efficacy in PCa cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSoares, S., Faria, I., Aires, F., Monteiro, A., Pinto, G., Sales, M. G., Correa-Duarte, M. A., Guerreiro, S. G., & Fernandes, R. (2023). Application of gold nanoparticles as radiosensitizer for metastatic prostate cancer cell lines. International Journal of Molecular Sciences, 24(4), Artigo 4. https://doi.org/10.3390/ijms24044122pt_PT
dc.identifier.doi10.3390/ijms24044122pt_PT
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10400.22/25187
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationThe author is grateful for the financial support of Foundation for Science and Technology (grant reference: SFRH/BD/138271/2018).pt_PT
dc.relation.publisherversionhttps://doi.org/10.3390/ijms24044122pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGold nanoparticlespt_PT
dc.subjectRadiotherapypt_PT
dc.subjectRadiosensitizing effectpt_PT
dc.subjectProstate cancerpt_PT
dc.subjectIn vitro assaypt_PT
dc.titleApplication of gold nanoparticles as radiosensitizer for metastatic prostate cancer cell linespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage20pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume24(4)pt_PT
person.familyNameSousa Pinho Faria
person.givenNameIsabel Maria
person.identifier.orcid0000-0002-1467-7800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb74bdeca-0113-40a8-ba5a-8fe2d558fe0e
relation.isAuthorOfPublication.latestForDiscoveryb74bdeca-0113-40a8-ba5a-8fe2d558fe0e

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