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Focused Neuroprotection in Parkinson's Disease: Effects of N-Acetylcysteine and MRI-guided Ultrasound Neuromodulation

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dc.contributor.authorSilva, Rita Caridade
dc.contributor.authorAraújo, B.
dc.contributor.authorVilaça-Ferreira, A. C.
dc.contributor.authorVilela, C.
dc.contributor.authorTeixeira, C.
dc.contributor.authorMartins-Macedo, J.
dc.contributor.authorSoares-Guedes, C.
dc.contributor.authorGomes, Eduardo D.
dc.contributor.authorMeriaux, S.
dc.contributor.authorLarrat, B.
dc.contributor.authorWade-Martins, R.
dc.contributor.authorFernandes, H. J.
dc.contributor.authorTeixeira, F.
dc.contributor.authorGomes, Eduardo
dc.date.accessioned2026-01-07T17:10:49Z
dc.date.available2026-01-07T17:10:49Z
dc.date.issued2025
dc.description.abstractParkinson’s Disease (PD) is characterized by a progressive degeneration of dopaminergic neurons (DAn) in the brain, leading to severe symptomatology. Current treatments mainly address motor symptoms rather than preventing DAn damage or degeneration. Hence, there is an urgent need for novel strategies, particularly those that can combine neuroprotective and neuroregenerative approaches [1]. Drug repurposing is a powerful method for identifying new applications for approved drugs outside the scope of the original medical indication [2]. Under this concept, N-acetylcysteine (NAC), a potent antioxidant, has shown therapeutic abilities in modulating oxidative stress and preventing dopamine-induced cell death [3], suggesting potential disease-modifying actions in PD. Notably, recent data from our team revealed that NAC could restore dopamine transporter (DAT) levels in the dorsal striatum of PD animals [4].eng
dc.identifier.citationSilva, R. C., Araújo, B., Vilaça-Ferreira, A. C., Vilela, C., Teixeira, C., Martins-Macedo, J., Soares-Guedes, C., Gomes, E. D., Mériaux, S., Larrat, B., Wade-Martins, R., Fernandes, H. J., & Teixeira, F. (2025). Focused Neuroprotection in Parkinson’s Disease: Effects of N-Acetylcysteine and MRI-guided Ultrasound Neuromodulation. Abstracts of the ECNP Workshop on Applied Neuroscience 2025 - Neuroscience Applied, Volume 4, Supplement 1, 47. https://doi.org/10.1016/j.nsa.2025.105496
dc.identifier.doi10.1016/j.nsa.2025.105496
dc.identifier.urihttp://hdl.handle.net/10400.22/31414
dc.language.isoeng
dc.peerreviewedn/a
dc.publisherElsevier
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S2772408525000882?via%3Dihub
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleFocused Neuroprotection in Parkinson's Disease: Effects of N-Acetylcysteine and MRI-guided Ultrasound Neuromodulationeng
dc.typeconference poster
dspace.entity.typePublication
oaire.citation.conferenceDate2025
oaire.citation.issueSupplement 1
oaire.citation.startPage47
oaire.citation.titleAbstracts of the ECNP Workshop on Applied Neuroscience 2025 - Neuroscience Applied
oaire.citation.volume4
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGomes
person.givenNameEduardo
person.identifier776948
person.identifier.ciencia-id7B13-B51D-97FF
person.identifier.orcid0000-0003-3179-1741
person.identifier.scopus-author-id55931679600
relation.isAuthorOfPublicationa4f4c0d1-5891-482a-a083-90a32e6ddc87
relation.isAuthorOfPublication.latestForDiscoverya4f4c0d1-5891-482a-a083-90a32e6ddc87

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