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Transgenerational inheritance of paternal neurobehavioral phenotypes: stress, addiction, ageing and metabolism

2015-11-16Journal article Open access
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dc.contributor.authorYuan, Ti-Fei
dc.contributor.authorLi, Ang
dc.contributor.authorSun, Xin
dc.contributor.authorOuyang, Huan
dc.contributor.authorCampos, Carlos
dc.contributor.authorRocha, Nuno
dc.contributor.authorArias-Carrión, Oscar
dc.contributor.authorMachado, Sergio
dc.contributor.authorHou, Gonglin
dc.contributor.authorSo, Kwok Fai
dc.date.accessioned2016-01-07T17:37:54Z
dc.date.available2016-11-01T01:30:09Z
dc.date.issued2015-11-16
dc.description.abstractEpigenetic modulation is found to get involved in multiple neurobehavioral processes. It is believed that different types of environmental stimuli could alter the epigenome of the whole brain or related neural circuits, subsequently contributing to the long-lasting neural plasticity of certain behavioral phenotypes. While the maternal influence on the health of offsprings has been long recognized, recent findings highlight an alternative way for neurobehavioral phenotypes to be passed on to the next generation, i.e., through the male germ line. In this review, we focus specifically on the transgenerational modulation induced by environmental stress, drugs of abuse, and other physical or mental changes (e.g., ageing, metabolism, fear) in fathers, and recapitulate the underlying mechanisms potentially mediating the alterations in epigenome or gene expression of offsprings. Together, these findings suggest that the inheritance of phenotypic traits through male germ-line epigenome may represent the unique manner of adaptation during evolution. Hence, more attention should be paid to the paternal health, given its equivalently important role in affecting neurobehaviors of descendants.pt_PT
dc.identifier.doi10.1007/s12035-015-9526-2pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/7331
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttp://link.springer.com/article/10.1007/s12035-015-9526-2pt_PT
dc.subjectTransgenerational inheritancept_PT
dc.subjectSpermpt_PT
dc.subjectEpigenetic modulationpt_PT
dc.subjectNeurobehaviorpt_PT
dc.titleTransgenerational inheritance of paternal neurobehavioral phenotypes: stress, addiction, ageing and metabolismpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMolecular Neurobiologypt_PT
person.familyNameCampos
person.familyNameRocha
person.givenNameCarlos
person.givenNameNuno
person.identifier192266
person.identifier.ciencia-idB518-6A52-D50F
person.identifier.ciencia-idAE16-A494-5F8B
person.identifier.orcid0000-0002-5966-4050
person.identifier.orcid0000-0002-3139-2786
person.identifier.ridM-9821-2013
person.identifier.scopus-author-id56567519500
person.identifier.scopus-author-id32867975300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf9744770-c154-483e-b271-b58d1089d55f
relation.isAuthorOfPublication9e940914-601a-4978-8d5b-74e5ade7ada7
relation.isAuthorOfPublication.latestForDiscoveryf9744770-c154-483e-b271-b58d1089d55f

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