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Recycling Old Antibiotics with Ionic Liquids

2020Journal article Open access
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dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorVieira, Mónica
dc.contributor.authorVan der Auweraer, Seppe
dc.contributor.authorFerraz, Ricardo
dc.date.accessioned2021-12-07T11:49:21Z
dc.date.available2021-12-07T11:49:21Z
dc.date.issued2020
dc.description.abstractAntibiotics are considered one of the great “miracles” of the 20th century. Now in the 21st century in the post-antibiotic era, the miracle is turning into a nightmare, due to the growing problem of the resistance of microorganisms to classic antimicrobials and the non-investment by the pharmaceutical industry in new antimicrobial agents. Unfortunately, the current COVID-19 pandemic has demonstrated the global risks associated with uncontrolled infections and the various forms of impact that such a pandemic may have on the economy and on social habits besides the associated morbidity and mortality. Therefore, there is an urgent need to recycle classic antibiotics, as is the case in the use of ionic liquids (ILs) based on antibiotics. Thus, the aim of the present review is to summarize the data on ILs, mainly those with antimicrobial action and especially against resistant strains. The main conclusions of this article are that ILs are flexible due to their ability to modulate cations and anions as a salt, making it possible to combine the properties of both and multiplying the activity of separate cations and anions. Also, these compounds have low cost methods of production, which makes it highly attractive to explore them, especially as antimicrobial agents and against resistant strains. ILs may further be combined with other therapeutic strategies, such as phage or lysine therapy, enhancing the therapeutic arsenal needed to fight this worldwide problem of antibacterial resistance. Thus, the use of ILs as antibiotics by themselves or together with phage therapy and lysine therapy are promising alternatives against pathogenic microorganisms, and may have the possibility to be used in new ways in order to restrain uncontrolled infections.pt_PT
dc.description.sponsorshipThis research was funded by Fundação para a Ciência e Tecnologia (FCT, Portugal), through grants UIDB/50006/2020 (to LAQV-REQUIMTE Research Unit) and also for project grant PTDC/BTM-SAL/29786/2017.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/antibiotics9090578pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/19015
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationA small couple against the big three
dc.relation.publisherversionhttps://www.mdpi.com/2079-6382/9/9/578/htmpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectIonic liquidspt_PT
dc.subjectActive pharmaceutical ingredientspt_PT
dc.subjectAntimicrobial agentspt_PT
dc.subjectAntibioticspt_PT
dc.titleRecycling Old Antibiotics with Ionic Liquidspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleA small couple against the big three
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTM-SAL%2F29786%2F2017/PT
oaire.citation.issue9pt_PT
oaire.citation.startPage578pt_PT
oaire.citation.titleAntibioticspt_PT
oaire.citation.volume9pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
person.familyNamePrudêncio
person.familyNameAlmeida Vieira
person.familyNameFerraz
person.givenNameCristina
person.givenNameMónica Andreia
person.givenNameRicardo
person.identifier1200571
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.ciencia-idA01E-9178-9B48
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.orcid0000-0002-9920-936X
person.identifier.orcid0000-0002-8687-4811
person.identifier.orcid0000-0002-1761-117X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id6508057930
person.identifier.scopus-author-id24464208500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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