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Natural Products for the Prevention and Treatment of Oral Mucositis—A Review

2022-04-15Journal article Open access
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dc.contributor.authorFerreira, Ana Sofia
dc.contributor.authorMacedo, Catarina
dc.contributor.authorSilva, Ana Margarida
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorCosta, Paulo
dc.contributor.authorRodrigues, Francisca
dc.date.accessioned2023-01-27T14:11:54Z
dc.date.available2023-01-27T14:11:54Z
dc.date.issued2022-04-15
dc.description.abstractCancer, a major world public health problem, is associated with chemotherapy treatments whose administration leads to secondary concerns, such as oral mucositis (OM). The OM disorder is characterized by the presence of ulcers in the oral mucosa that cause pain, bleeding, and difficulty in ingesting fluids and solids, or speaking. Bioactive compounds from natural sources have arisen as an effective approach for OM. This review aims to summarize the new potential application of different natural products in the prevention and treatment of OM in comparison to conventional ones, also providing a deep insight into the most recent clinical studies. Natural products, such as Aloe vera, Glycyrrhiza glabra, Camellia sinensis, Calendula officinalis, or honeybee crops, constitute examples of sources of bioactive compounds with pharmacological interest due to their well-reported activities (e.g., antimicrobial, antiviral, anti-inflammatory, analgesic, or wound healing). These activities are associated with the bioactive compounds present in their matrix (such as flavonoids), which are associated with in vivo biological activities and minimal or absent toxicity. Finally, encapsulation has arisen as a future opportunity to preserve the chemical stability and the drug bioa vailability of bioactive compounds and, most importantly, to improve the buccal retention period and the therapeutic effectspt_PT
dc.description.sponsorshipThis research was funded by the project EXPL/BAA-GR/0663/2021—Kiwi4Health—Exploring the Eco-Innovative Re-Use of Kiwiberry, supported by national funds from Fundação para a Ciência e a Tecnologia (Portugal), as well as the project MTS/SAS/0077/2020-Honey+-New reasons to care honey from the Natural Park of Montesinho: A bioindicator of environmental quality & its therapeutic potential. Ana Sofia Ferreira (SFRH/BD/7519/2020) and Ana Margarida Silva (SFRH/BD/144994/2019) are thankful for their Ph.D. grants financed by POPH-QREN and subsidized by the European Science Foundation and Ministério da Ciência, Tecnologia e Ensino Superior. Catarina Macedo is thankful for her scholarship from the project EXPL/BAA-GR/0663/2021. Francisca Rodrigues (CEECIND/01886/2020) is thankful for her contract financed by FCT/MCTES—CEEC Individual Program Contract. This work was financially supported by Portuguese national funds through projects UIDB/50006/2020, UIDP/50006/2020, and LA/P/0008/2020, from the Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES). This work was also financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences—UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HBpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ijms23084385pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/21950
dc.language.isoengpt_PT
dc.publisherMDPIpt_PT
dc.relationSFRH/BD/7519/2020pt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationFrom soil to skin: Eco-friendly extract from kiwiberry leaves for prevention of skin aging process
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/23/8/4385pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCancerpt_PT
dc.subjectDrug deliverypt_PT
dc.subjectNatural productspt_PT
dc.subjectOral mucositispt_PT
dc.subjectTreatmentpt_PT
dc.titleNatural Products for the Prevention and Treatment of Oral Mucositis—A Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleFrom soil to skin: Eco-friendly extract from kiwiberry leaves for prevention of skin aging process
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/MTS%2FSAS%2F0077%2F2020/PT
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oaire.citation.issue8pt_PT
oaire.citation.startPage4385pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume23pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
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oaire.fundingStreamPOR_NORTE
person.familyNameFerreira
person.familyNamePinheiro Macedo
person.familyNameSilva
person.familyNameDelerue-Matos
person.familyNamePinto Lisboa Martins Rodrigues Sarmento
person.givenNameAna Sofia
person.givenNameCatarina
person.givenNameAna Margarida
person.givenNameCristina
person.givenNameFrancisca
person.identifier2496526
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person.identifier.ciencia-id4F19-3D98-2CBA
person.identifier.orcid0000-0001-5268-4932
person.identifier.orcid0000-0002-6108-8582
person.identifier.orcid0000-0002-1823-9816
person.identifier.orcid0000-0002-3924-776X
person.identifier.orcid0000-0001-8803-0041
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id57203495060
person.identifier.scopus-author-id6603741848
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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