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Quercetin-biapigenin nanoparticles are effective to penetrate the blood–brain barrier

2021-03Journal article Open access
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dc.contributor.authorOliveira, Ana
dc.contributor.authorPinho, Cláudia
dc.contributor.authorSarmento, Bruno
dc.contributor.authorDias, Alberto C. P.
dc.date.accessioned2021-03-26T14:41:20Z
dc.date.available2022-03-01T01:30:28Z
dc.date.issued2021-03
dc.description.abstractSearch for efficient therapeutic agents for central nervous system (CNS) disorders has been extensive. Nevertheless, blood-brain barrier (BBB) is an obstacle that prevents the majority of compounds to act in these diseases. It is, thus, of extreme relevance the BBB overcome, in order to deliver a drugs therapeutically active concentration to the action site, with the least losses and interaction with other organs, tissues, or cells. The present study aimed to investigate the potential protective effect of quercetin-biapigenin encapsulated into poly(Ɛ-polycaprolactone) (PCL) nanoparticles against t-BOOH-induced oxidative stress in several brain cell lines, as well as evaluate the permeability of those active molecules through an in vitro BBB model. The three cell lines under study (BV-2, hcmec/D3, and U87) presented different reactions to t-BOOH. In general, quercetin-biapigenin PCL-loaded nanoparticles were able to minimize compound toxicity they convey, regardless the cell line. Quercetin-biapigenin PCL-loaded nanoparticles (Papp of approximately 80 × 10-6 cm/s) revealed to be more permeable than free compounds (Papp of approximately 50 × 10-6 cm/s). As of our knowledge, this is the first report of quercetin-biapigenin PCL-loaded nanoparticle activity in brain cells. It is also the first determining its permeability through BBB, as an effective nanocarrier for brain delivery.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOliveira, A. I., Pinho, C., Sarmento, B., & Dias, A. C. P. (2021). Quercetin-biapigenin nanoparticles are effective to penetrate the blood–brain barrier. Drug Delivery and Translational Research. https://doi.org/10.1007/s13346-021-00917-6pt_PT
dc.identifier.doi10.1007/s13346-021-00917-6pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/17683
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs13346-021-00917-6pt_PT
dc.subjectQuercetinpt_PT
dc.subjectBiapigeninpt_PT
dc.subjectPoly(ɛ-polycaprolactone)pt_PT
dc.subjectNanoparticlespt_PT
dc.subjectNeuroprotectionpt_PT
dc.subjectPermeabilitypt_PT
dc.titleQuercetin-biapigenin nanoparticles are effective to penetrate the blood–brain barrierpt_PT
dc.typejournal article
dspace.entity.typePublication
person.familyNameOliveira
person.familyNamePinho
person.givenNameAna Isabel
person.givenNameCláudia
person.identifier.ciencia-id9212-F501-E9EF
person.identifier.ciencia-id8B1B-A0D9-B6E4
person.identifier.orcid0000-0003-4420-6476
person.identifier.orcid0000-0002-3157-3712
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4b3fe293-2740-469f-97d3-99d0b107b5e0
relation.isAuthorOfPublication01c994b8-cb20-43a8-947c-d2b978283944
relation.isAuthorOfPublication.latestForDiscovery01c994b8-cb20-43a8-947c-d2b978283944

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