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Cellulose‑based hydrogel on quantum dots with molecularly imprinted polymers for the detection of CA19‑9 protein cancer biomarker

2024Lecture Open access
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dc.contributor.authorPiloto, Ana Margarida L.
dc.contributor.authorRibeiro, David S.M.
dc.contributor.authorRodrigues, S. Sofia M.
dc.contributor.authorSantos, João L.M.
dc.contributor.authorSampaio, Paula
dc.contributor.authorSales, Maria Goreti Ferreira
dc.date.accessioned2024-11-08T14:03:43Z
dc.date.available2024-11-08T14:03:43Z
dc.date.issued2024
dc.description.abstractMolecularly imprinted polymers (MIPs), were successfully assembled around quantum dots (QDs), for the detection of the carbohydrate antigen CA19-9, a biomarker associated with pancreatic cancer (PC). The imprinted materials MIP@QDs were incorporated within cellulose hydrogels and designated as imprinted hydrogels (iHGs). The concept is to use MIPs which function as the biorecognition elements, conjugated to QDs as the sensing system. The fluorescence quenching of the iHGs occurred with increasing concentrations of CA19-9, showing linearity in the range 2.76 × 10−2 – 5.23 × 102 U/ml, in a 1000-fold diluted human serum. The iHGs show a linear response below the cutoff values for pancreatic cancer diagnosis (< 23 U/ml), a limit of detection of 1.58 × 10−3 U/ml and an imprinting factor (IF) of 1.76. Moreover, they exhibit stability and selectivity towards CA19-9, when compared with the non-imprinted controls, here designated as non-imprinted hydrogels (non-iHGs). In conclusion, this work demonstrates that the conjugation of MIPs to QDs increases the sensitivity and specificity of the developed sensing system for optical detection methods within clinical significance ranges. This fact shows potential for the iHGs to be applied as a sensitive, low-cost format for point-of-care tests (PoCTs).pt_PT
dc.description.versionN/Apt_PT
dc.identifier.citationPiloto, A.M.L., Ribeiro, D.S.M., Rodrigues, S.S.M., Santos, J.L.M., Sampaio, P., & Sales, M.G.F. (2024, May 23-24). Cellulose-based hydrogel on quantum dots with molecularly imprinted polymers for the detection of CA19-9 protein cancer biomarker [Abstract]. VII iBiMED Symposium: Sharing science, inspiring progress, University of Aveiro, Aveiro, Portugal.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/26364
dc.language.isoengpt_PT
dc.relationCellulose bio-nanocomposites as test-strips for protein cancer biomarkers
dc.relationNovos sitemas óticos biomiméticos para o seguimento de biomarcadores de cancro
dc.relationCenter for Innovation in Industrial Engineering and Technology
dc.relationCenter for Innovation in Industrial Engineering and Technology
dc.subjectCarbohydrate antigen A 19–9pt_PT
dc.subjectPancreatic cancer diagnosispt_PT
dc.subjectQuantum dotspt_PT
dc.subjectMolecularly imprinted polymerspt_PT
dc.subjectOptical sensorpt_PT
dc.subjectImprinted cellulose hydrogelspt_PT
dc.titleCellulose‑based hydrogel on quantum dots with molecularly imprinted polymers for the detection of CA19‑9 protein cancer biomarkerpt_PT
dc.typelecture
dspace.entity.typePublication
oaire.awardTitleCellulose bio-nanocomposites as test-strips for protein cancer biomarkers
oaire.awardTitleNovos sitemas óticos biomiméticos para o seguimento de biomarcadores de cancro
oaire.awardTitleCenter for Innovation in Industrial Engineering and Technology
oaire.awardTitleCenter for Innovation in Industrial Engineering and Technology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F116067%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022/2022.07897.PTDC/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04730%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04730%2F2020/PT
oaire.citation.conferencePlaceUniversity of Aveiro, Aveiro, Portugal.pt_PT
oaire.citation.titleVII iBiMED Symposium: Sharing science, inspiring progresspt_PT
oaire.fundingStreamConcurso de Projetos de I&D em Todos os Domínios Científicos - 2022
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameL. Piloto Cerqueira
person.familyNameRibeiro
person.familyNameM. Rodrigues
person.familyNameSantos
person.familyNameSampaio Fonseca
person.familyNameFerreira Sales
person.givenNameAna Margarida
person.givenNameDavid
person.givenNameS. Sofia
person.givenNameJoão L.M.
person.givenNamePaula Maria
person.givenNameMaria Goreti
person.identifierR-000-722
person.identifierhttps://scholar.google.pt/citations?user=4s7GcN8AAAAJ&hl=en&oi=ao
person.identifier826970
person.identifier.ciencia-idAD1C-28E2-F781
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person.identifier.ciencia-idD11C-C8B6-CA21
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person.identifier.ciencia-id8F14-D1AD-2732
person.identifier.ciencia-idE31F-1630-42BB
person.identifier.orcid0000-0002-2374-2467
person.identifier.orcid0000-0001-7879-0143
person.identifier.orcid0000-0002-9891-6994
person.identifier.orcid0000-0003-3947-6025
person.identifier.orcid0000-0003-1148-2159
person.identifier.orcid0000-0001-9936-7336
person.identifier.ridG-5788-2018
person.identifier.ridD-5818-2013
person.identifier.ridF-1026-2015
person.identifier.ridD-5923-2013
person.identifier.ridK-9199-2013
person.identifier.scopus-author-id8527885100
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person.identifier.scopus-author-id25628662600
person.identifier.scopus-author-id7004066810
person.identifier.scopus-author-id7005174717
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typelecturept_PT
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