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Sensitivity of psychophysical, electrophysiological and structural tests for detection and progression monitoring in ocular hypertension and glaucoma

2018-05-09Journal article Open access
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dc.contributor.authorRaimundo, Miguel
dc.contributor.authorMateus, Catarina
dc.contributor.authorFaria, Pedro
dc.contributor.authorOliveiros, Bárbara
dc.contributor.authorCardoso, João
dc.contributor.authorSilva, João Filipe
dc.contributor.authorPereira, José Moura
dc.contributor.authorCastelo-Branco, Miguel
dc.date.accessioned2024-12-02T16:17:34Z
dc.date.available2024-12-02T16:17:34Z
dc.date.issued2018-05-09
dc.description.abstractTo characterize early visual impairment of patients in the glaucoma spectrum, using psychophysical, electrophysiological and structural methods. Cohort of 52 patients, 18 patients with ocular hypertension (HT), 15 glaucoma suspects (GS) and 19 with primary open-angle glaucoma (G), and 20 age-matched controls. Quantitative psychophysical methods were used to assess magno (FDT, Frequency Doubling Technology), parvo and koniocellular pathways (Cambridge Color Test), and RGC function was assessed by Pattern Electroretinogram. RGC axonal thickness was obtained using OCT. Reduced mean achromatic contrast sensitivity (p=0.0298) was found in patients with HT, as well as a reduced PERG N-95 wave amplitude (p=0.0499). Chromatic thresholds were significantly increased for protan, deutan and tritan axes (p<0.03) in these patients when compared to controls. At approximately 80% specificity, FDT showed only moderate sensitivity to detect early functional damage (superior nasal, 66% sensitivity). The pattern of disease progression decline is approximately linear for all tests, but more severe in OCT, RNFL thickness ( = 0.47). We found relative damage of magno, parvo and koniocellular retinocortical pathways beginning in ocular hypertension. FDT and CCT Protan performed well in detecting early damage in ocular hypertension, whereas longitudinal analysis using OCT for RFNL appeared to be the best to monitor the progression. The sensitivity of currently available tests is lower comparing with our previously reported novel psychophysical tools (sensitivity above 90% for 80% specificity). We believe early diagnosis in glaucoma is possible by exploiting visual pathways with a small degree of redundancy through high sensitivity functional tests.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRaimundo, M., Mateus, C., Faria, P., Oliveiros, B., Cardoso, J., Silva, J. F., Pereira, J. M., & Castelo-Branco, M. (2018). Sensitivity of psychophysical, electrophysiological and structural tests for detection and progression monitoring in ocular hypertension and glaucoma. Revista Sociedade Portuguesa de Oftalmologia, 42(1), Artigo 1. https://doi.org/10.48560/rspo.13563pt_PT
dc.identifier.doi10.48560/rspo.13563pt_PT
dc.identifier.eissn1646-6950
dc.identifier.urihttp://hdl.handle.net/10400.22/26598
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Portuguesa de Oftalmologiapt_PT
dc.relation.publisherversionhttps://revistas.rcaap.pt/index.php/oftalmologia/article/view/13563pt_PT
dc.subjectGlaucomapt_PT
dc.subjectOcular hypertensionpt_PT
dc.subjectStandard automated perimetrypt_PT
dc.subjectOptical coherence tomographypt_PT
dc.subjectFrequency doubling technologypt_PT
dc.subjectPattern electroretinogrampt_PT
dc.subjectColor visionpt_PT
dc.subjectMagnocelullarpt_PT
dc.subjectkoniocellularpt_PT
dc.subjectParvocelullarpt_PT
dc.titleSensitivity of psychophysical, electrophysiological and structural tests for detection and progression monitoring in ocular hypertension and glaucomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleRevista Sociedade Portuguesa de Oftalmologiapt_PT
oaire.citation.volume42 (1)pt_PT
person.familyNameMateus
person.givenNameCatarina
person.identifier.ciencia-id2511-2C7F-6252
person.identifier.orcid0000-0003-4472-5049
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7433c2c9-3ce3-4ad8-b268-7255233bda5b
relation.isAuthorOfPublication.latestForDiscovery7433c2c9-3ce3-4ad8-b268-7255233bda5b

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