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Policy measures and instruments used in European countries to increase biosimilar uptake: a systematic review

2024-02-28Journal article Open access
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dc.contributor.authorMachado, Sara 
dc.contributor.authorCruz, Agostinho
dc.contributor.authorFerreira, Pedro Lopes 
dc.contributor.authorMorais, Carminda 
dc.contributor.authorPimenta, Rui
dc.date.accessioned2024-04-23T15:23:25Z
dc.date.available2024-04-23T15:23:25Z
dc.date.issued2024-02-28
dc.description.abstractWhile biosimilar medicines can contribute to the sustainability of healthcare systems, their utilization rate varies across European countries. This study aims to identify and systematize policy measures and instruments used in European countries to increase biosimilar market share. A systematic review was conducted according to PRISMA 2020 recommendations. Medline-PubMed, Web of Science and ScienceDirect databases were searched using inclusion criteria that required full articles published in English between January 2006 and November 2023. Reviews, letters, reports, editorials and comments or opinion articles were excluded from this study. Of the 1,137 articles, only 13 met the eligibility criteria for analysis, which covered a total of 28 European countries. Pricing regulation measures were found in 27 of these countries with tendering, price-linkage and internal reference price being the most used. Tendering was used by 27 countries to procure biosimilars in inpatient setting. Prescribing guidelines and recommendations were the widely used instrument. Some European countries adopted physician incentives, quotas, and prescription by international non-proprietary name. Automatic substitution was not commonly recommended or applied. Interchangeability and switching will become increasingly relevant issues. It is important that the positive results from some countries serve as an example for the future of these medicines in the European market.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMachado, S., Cruz, A., Ferreira, P. L., Morais, C., & Pimenta, R. E. (2024). Policy measures and instruments used in European countries to increase biosimilar uptake: A systematic review. Frontiers in Public Health, 12, 1–9. https://doi.org/10.3389/fpubh.2024.1263472pt_PT
dc.identifier.doi10.3389/fpubh.2024.1263472pt_PT
dc.identifier.issn2296-2565
dc.identifier.urihttp://hdl.handle.net/10400.22/25399
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationThe author(s) declare financial support was received for the research, authorship, and/or publication of this article. CEISUC/CIBB is funded by national funds through FCT Foundation for Science and Technology, I.P., under the Multiannual Financing of R&D Units 2020–2023.pt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1263472/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBiological productspt_PT
dc.subjectBiosimilar pharmaceuticalspt_PT
dc.subjectDrug substitutionpt_PT
dc.subjectHealth policypt_PT
dc.subjectEconomicspt_PT
dc.titlePolicy measures and instruments used in European countries to increase biosimilar uptake: a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage9pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Public Healthpt_PT
oaire.citation.volume12pt_PT
person.familyNameCruz
person.familyNamePimenta
person.givenNameAgostinho
person.givenNameRui
person.identifier846820
person.identifier.ciencia-idD914-641B-E379
person.identifier.orcid0000-0002-1157-8196
person.identifier.orcid0000-0002-1985-8395
person.identifier.ridJUU-6485-2023
person.identifier.scopus-author-id56340941800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd7ec3c5d-b3e0-4e34-8e24-4d1588876120
relation.isAuthorOfPublicationb4e32df4-4e68-4964-9380-791b450a972b
relation.isAuthorOfPublication.latestForDiscoveryb4e32df4-4e68-4964-9380-791b450a972b

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