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Hormonal, neurochemical, and behavioral response to a forced swim test in adolescent rats throughout cocaine withdrawal

2008-10-06Journal article Restricted access
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dc.contributor.authorAlves, Cecília Juliana
dc.contributor.authorMagalhães, Ana
dc.contributor.authorSummavielle, Teresa
dc.contributor.authorMelo, Pedro
dc.contributor.authorSousa, Liliana De
dc.contributor.authorTavares, Maria Amélia
dc.contributor.authorMonteiro, Pedro
dc.date.accessioned2022-06-02T15:17:40Z
dc.date.available2022-06-02T15:17:40Z
dc.date.issued2008-10-06
dc.description.abstractThe use of cocaine in adults has been linked to depression and/or anxiety. Several studies have shown an association between cocaine-primed craving and depressive symptoms. In animal models, the forced swim test (FST) is frequently used for screening depressive-like behavior. This study aimed to verify the presence of depression-like symptoms in adolescent rats after chronic cocaine exposure by analyzing behavior in a FST. The subsequent alterations in neurotransmitters and hypothalamus-pituitary-adrenal axis activity induced by this test were also analyzed. Both male and female adolescent Wistar rats were submitted to a chronic “binge” pattern of administration of cocaine hydrochloride, and subjects were tested in a forced swim test 2 days after cocaine's last administration. At the end of the behavioral test, trunk blood was collected for quantification of corticosterone plasma levels, and hypothalamus, prefrontal cortex, amygdala, and hippocampus were dissected for neurochemical determinations. No significant differences were found in the behavior on the FST of both males and females after withdrawal from chronic cocaine administration. Nevertheless, plasma levels of corticosterone were increased in cocaine-treated males, although not significantly (P= 0.065). In females cocaine failed to affect corticosterone levels. Of interest, neurochemical analyses showed that dopamine turnover was decreased in amygdala in cocaine-treated males (not significantly, P= 0.055). No significant differences were found on neurotransmitter levels in the other brain regions analyzed. Withdrawal from chronic cocaine administration during adolescence did not have a significant effect on stress-induced behavioral alterations, although the neurochemical response to the stressful situation provided by FTS seemed to be affected.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlves, C. J., Magalhães, A., Summavielle, T., Melo, P., De Sousa, L., Tavares, M. A., & Monteiro, P. R. R. (2008). Hormonal, Neurochemical, and Behavioral Response to a Forced Swim Test in Adolescent Rats throughout Cocaine Withdrawal. Annals of the New York Academy of Sciences, 1139(1), 366-373. https://doi.org/https://doi.org/10.1196/annals.1432.047pt_PT
dc.identifier.doi10.1196/annals.1432.047pt_PT
dc.identifier.eissn1749-6632
dc.identifier.issn0077-8923
dc.identifier.urihttp://hdl.handle.net/10400.22/20585
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNew York Academy of Sciencespt_PT
dc.relation.publisherversionhttps://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1196/annals.1432.047pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectCocainept_PT
dc.subjectChronic exposurept_PT
dc.subjectWithdrawalpt_PT
dc.subjectAdolescencept_PT
dc.subjectRatpt_PT
dc.subjectForced swim testpt_PT
dc.subjectBehaviorpt_PT
dc.subjectMonoaminespt_PT
dc.subjectCorticosteronept_PT
dc.titleHormonal, neurochemical, and behavioral response to a forced swim test in adolescent rats throughout cocaine withdrawalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage373pt_PT
oaire.citation.startPage366pt_PT
oaire.citation.titleANNALS of New York Academy of Sciencespt_PT
oaire.citation.volume1139pt_PT
person.familyNameSummavielle
person.familyNameMonteiro
person.givenNameTeresa
person.givenNamePedro
person.identifier677706
person.identifier.ciencia-idC41E-0816-5C85
person.identifier.ciencia-id2414-4468-928B
person.identifier.orcid0000-0003-2548-6281
person.identifier.orcid0000-0002-3991-9191
person.identifier.ridC-9776-2012
person.identifier.scopus-author-id6603092949
person.identifier.scopus-author-id6504494827
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication207ee2de-85a0-4144-9e7e-b376c600e065
relation.isAuthorOfPublicationfae8b5b3-db39-4d56-a2b1-2db0388279b9
relation.isAuthorOfPublication.latestForDiscoveryfae8b5b3-db39-4d56-a2b1-2db0388279b9

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