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CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progression

2024-10Research article Open access
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dc.contributor.authorCardoso, Marcos S.
dc.contributor.authorGonçalves, Rute
dc.contributor.authorOliveira, Liliana
dc.contributor.authorSilvério, Diogo
dc.contributor.authorTéllez, Erica
dc.contributor.authorPaul, Tony
dc.contributor.authorSarrias, Maria Rosa
dc.contributor.authorCarmo, Alexandre M.
dc.contributor.authorSaraiva, Margarida
dc.date.accessioned2025-11-21T16:31:25Z
dc.date.available2025-11-21T16:31:25Z
dc.date.issued2024-10
dc.description.abstractTuberculosis (TB) alone caused over a billion deaths in the last 200 years, making it one of the deadliest diseases to humankind. Understanding the immune mechanisms underlying protection or pathology in TB is key to uncover the much needed innovative approaches to tackle TB. The scavenger receptor cysteine-rich molecule CD5 antigen-like (CD5L) has been associated with TB, but whether and how CD5L shapes the immune response during the course of disease remains poorly understood. Here, we show an upregulation of CD5L in circulation and at the site of infection in C57BL/6 Mycobacterium tuberculosis-infected mice. To investigate the role of CD5L in TB, we studied the progression of M. tuberculosis aerosol infection in a recently described genetically engineered mouse model lacking CD5L. Despite the increase of CD5L during infection of wild-type mice, absence of CD5L did not impact bacterial burden, histopathology or survival of infected mice. Absence of CD5L associated with a modest increase in the numbers of CD4+ T cells and the expression of IFN-γ in the lungs of infected mice, with no major effect in overall immune cell dynamics. Collectively, this study confirms CD5L as a potential diagnostic biomarker to TB, showing no discernible impact on the outcome of the infection.por
dc.identifier.citationCardoso, M. S., Gonçalves, R., Oliveira, L., Silvério, D., Téllez, É., Paul, T., Sarrias, M. R., Carmo, A. M., & Saraiva, M. (2024). CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progression. Immunology, 173(2), 310–320. https://doi.org/10.1111/imm.13825
dc.identifier.doi10.1111/imm.13825
dc.identifier.eissn1365-2567
dc.identifier.issn0019-2805
dc.identifier.urihttp://hdl.handle.net/10400.22/31017
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relationPTDC/SAU-INF/1172/2021
dc.relation.hasversionhttps://onlinelibrary.wiley.com/doi/10.1111/imm.13825
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCD5L
dc.subjectImmune response
dc.subjectMacrophage
dc.subjectT cells
dc.subjectTuberculosis
dc.titleCD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progressionpor
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.endPage320
oaire.citation.issue2
oaire.citation.startPage310
oaire.citation.titleImmunology
oaire.citation.volume173
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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