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Assessment of 83 pharmaceuticals in WWTP influent and effluent samples by UHPLC-MS/MS: Hourly variation

2019Journal article Open access
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dc.contributor.authorPaíga, Paula
dc.contributor.authorCorreia, Manuela
dc.contributor.authorFernandes, Maria João
dc.contributor.authorSilva, Ana Margarida
dc.contributor.authorMartins de Carvalho, Maria Manuela
dc.contributor.authorVieira, Joana
dc.contributor.authorJorge, Sandra
dc.contributor.authorSilva, Jaime Gabriel
dc.contributor.authorFreire, Cristina
dc.contributor.authorDelerue-Matos, Cristina
dc.date.accessioned2020-10-30T12:15:18Z
dc.date.available2020-10-30T12:15:18Z
dc.date.issued2019
dc.description.abstractThe removal efficiency of pharmaceuticals in wastewater treatment plants (WWTPs) is variable and some of these compounds pass these plants almost intact and others presenting a removal efficiency close to 100%. Their incomplete removal results in a continuous discharge of pharmaceuticals into the environment. To assess the profile of contamination of influents and effluents over a day, a set of 83 pharmaceuticals were evaluated hourly in a WWTP in Leiria, Portugal. The composite samples of the influent and effluent were also collected. Concentrations varied from <MDL for ketoprofen, clarithromycin, ofloxacin, and diltiazem to 63.97 μg/L for caffeine in the WWTP influent composite sample and <MDL for clarithromycin, bupropion, and diltiazem to 2.01 μg/L for O-desmethylvenlafaxine for effluent composite sample. Concentrations in the range of μg/L were found for hydroxyibuprofen, salicylic acid, d,l-norephedrine, and caffeine in the WWTP influent, and diclofenac, carbamazepine, O-desmethylvenlafaxine in the WWTP effluents. For the samples collected hourly, thirty-eight and twenty-nine pharmaceuticals were detected in at least one WWTP sample. In the WWTP influent the total concentration of detected pharmaceuticals was higher between 15 and 22 h and lower in the period from 23 to 10 h in the morning. In the WWTP effluent, a slight variation was noticed throughout the sampling hours. Carbamazepine, fluoxetine, sertraline, atorvastatin, caffeine, simvastatin, and trazodone were the pharmaceuticals with risk quotient (RQ) >1 in WWTP influents, and carbamazepine, fluoxetine, sertraline the pharmaceuticals with an RQ > 1 in WWTP effluents.pt_PT
dc.description.sponsorshipThe Fundação para a Ciência e a Tecnologia, Portugal (FCT), FEDER under Programme PT2020 (Project UID/QUI/50006/2013-POCI/01/0145/FEDER/007265) and Programme FCT–UT Austin, Emerging Technologies (Project UTAP-ICDT/CTM-NAN/0025/2014) is acknowledged for the financial funding. The authors would like to thank also the EU and FCT/UEFISCDI, Romania/The Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS), Sweden for funding, in the frame of the collaborative international consortium REWATER financed under the ERA-NET Cofund WaterWorks2015 Call. This ERA-NET is an integral part of the 2016 Joint Activities developed by the Water Challenges for a Changing World Joint Programme Initiative (Water JPI). The authors would like to thank the staff of WWTP for their collaboration by collecting the samples.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.scitotenv.2018.08.129pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/16393
dc.language.isoengpt_PT
dc.subjectChromatographypt_PT
dc.subjectPharmaceutical Preparationspt_PT
dc.subjectPortugalpt_PT
dc.subjectTandem Mass Spectrometrypt_PT
dc.subjectTime Factorspt_PT
dc.subjectWaste Disposalpt_PT
dc.subjectWater Pollutantspt_PT
dc.subjectEnvironmental Monitoringpt_PT
dc.subjectWastewaterspt_PT
dc.subjectHourly sample collectionpt_PT
dc.subjectMass spectrometrypt_PT
dc.subjectPharmaceuticalspt_PT
dc.subjectSolid phase extractionpt_PT
dc.subjectUHPLC-MS/MSpt_PT
dc.titleAssessment of 83 pharmaceuticals in WWTP influent and effluent samples by UHPLC-MS/MS: Hourly variationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.citation.endPage600pt_PT
oaire.citation.startPage582pt_PT
oaire.citation.titleScience of the Total Environmentpt_PT
oaire.citation.volume648pt_PT
oaire.fundingStream5876
person.familyNamePaíga
person.familyNameCorreia
person.familyNameFernandes
person.familyNameSilva
person.familyNameMartins de Carvalho
person.familyNameDelerue-Matos
person.givenNamePaula
person.givenNameManuela
person.givenNameMaria João
person.givenNameAna Margarida
person.givenNameMaria Manuela
person.givenNameCristina
person.identifier1668889
person.identifier1552042
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person.identifier.ciencia-idBC18-CB0A-E027
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person.identifier.ciencia-id6B1F-B899-5516
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0002-9593-1355
person.identifier.orcid0000-0002-3014-5089
person.identifier.orcid0000-0002-1840-4439
person.identifier.orcid0000-0002-1823-9816
person.identifier.orcid0000-0003-3565-4496
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridQ-4930-2018
person.identifier.ridD-8725-2013
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id6506638953
person.identifier.scopus-author-id7102145897
person.identifier.scopus-author-id57203385978
person.identifier.scopus-author-id57203495060
person.identifier.scopus-author-id6603741848
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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