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Ensuring safety in cytotoxic drug preparation: A systematic review of guidelines addressing education for pharmacy professionals

2025-02-13Research article Open access
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dc.contributor.authorMoreira, Fernando
dc.contributor.authorJesus, Ângelo
dc.contributor.authorPinho, Cláudia
dc.contributor.authorSantos, Marlene
dc.contributor.authorSerdoura, Mélanie
dc.contributor.authorCruz, Agostinho
dc.contributor.authorMoreira, Fernando
dc.contributor.authorJesus, Ângelo
dc.contributor.authorPinho, Cláudia
dc.contributor.authorSantos, Marlene
dc.contributor.authorCruz, Agostinho
dc.date.accessioned2025-04-08T10:30:19Z
dc.date.available2025-04-08T10:30:19Z
dc.date.issued2025-02-13
dc.description.abstractChemotherapy preparation involves the use of specific techniques and equipment, given the need to maintain preparation sterility and its strict prescribed composition, and avoid occupational exposure to cytotoxic agents. This study aims to identify the most relevant contents for pharmacy professionals' education and training programs and to elucidate the evaluation procedure these professionals should follow when handling cytotoxics. We adopted the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines in conducting and reporting this systematic review. We conducted a literature search in PubMed, Cochrane, and LILACS to identify guidelines on cytotoxic drug preparation published between 2004 and 2024. Inclusion criteria included guidelines written in English, Spanish, or Portuguese that addressed the education, training, and/or evaluation of pharmacy professionals involved in handling cytotoxic drugs. We excluded guidelines developed for other health professionals (e.g. nurses) and guidelines exclusively addressing the manipulation of oral dosage forms. Citation searching was also performed to avoid search biases. Three researchers independently selected 20 guidelines that met the inclusion criteria, out of 3781 unique references identified. Four appraisers assessed the guidelines using the AGREE-II tool. Recommendations for training in cytotoxic drug handling generally included pre-initiation and periodic assessment. Personal protective equipment and engineering controls use, spill management, and aseptic technique were the most frequently mentioned specific training contents. We have developed a training proposal based on the guidelines, with four training levels that address the specific identified content. Each level presents potential competency assessment strategies. Included publications frequently recognized that conducting educational programs before and during the preparation of cytotoxic drugs was important and the combination of theoretical and practical learning seems of the utmost relevance. The development or update of guidelines in this area should prioritize their effective applicability to facilitate their implementation.por
dc.identifier.citationMoreira, F., Jesus, Â., Pinho, C., Santos, M., Serdoura, M., & Cruz, A. (2025). Ensuring safety in cytotoxic drug preparation: A systematic review of guidelines addressing education for pharmacy professionals. Journal of the American Pharmacists Association, 102352. https://doi.org/10.1016/j.japh.2025.102352
dc.identifier.doi10.1016/j.japh.2025.102352
dc.identifier.eissn1544-3450
dc.identifier.issn1544-3191
dc.identifier.urihttp://hdl.handle.net/10400.22/29937
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation10.54499/LA/P/0008/2020, 10.54499/UIDP/50006/2020; 10.54499/UIDB/50006/2020
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/abs/pii/S1544319125000317?via%3Dihub
dc.rights.uriN/A
dc.subjectPharmacy service
dc.subjectHospital
dc.subjectPractice guideline
dc.subjectProfessional competence
dc.subjectSafety
dc.subjectStaff development
dc.titleEnsuring safety in cytotoxic drug preparation: A systematic review of guidelines addressing education for pharmacy professionalspor
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.titleJournal of the American Pharmacists Association
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aa
person.familyNameMoreira
person.familyNameJesus
person.familyNamePinho
person.familyNameSantos
person.familyNameCruz
person.givenNameFernando
person.givenNameÂngelo
person.givenNameCláudia
person.givenNameMarlene
person.givenNameAgostinho
person.identifier2947760
person.identifier1508370
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person.identifier.ciencia-idA91F-3585-4F42
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person.identifier.ciencia-id8311-B967-31C4
person.identifier.orcid0000-0002-3452-1459
person.identifier.orcid0000-0003-3972-8253
person.identifier.orcid0000-0002-3157-3712
person.identifier.orcid0000-0001-5020-5942
person.identifier.orcid0000-0002-1157-8196
person.identifier.ridA-4404-2012
person.identifier.scopus-author-id56153841300
person.identifier.scopus-author-id57110502000
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relation.isAuthorOfPublication.latestForDiscovery81213e80-09a5-4655-93dc-e54199edb2fe

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