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Influence of il6-174g>c, il6-6331t>c and il6r d358a a>c il-6 genetic polymorphisms in antidepressant treatment phenotypes

2014-08-01Journal article Open access
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dc.contributor.authorSantos, Marlene
dc.contributor.authorCarvalho, Serafim
dc.contributor.authorLima, Luís
dc.contributor.authorMota-Pereira, Jorge
dc.contributor.authorPimentel, Paulo
dc.contributor.authorMaia, Dulce
dc.contributor.authorCorreia, Diana
dc.contributor.authorGomes, Sofia
dc.contributor.authorCruz, Agostinho
dc.contributor.authorMedeiros, Rui
dc.date.accessioned2023-09-14T15:29:18Z
dc.date.available2023-09-14T15:29:18Z
dc.date.issued2014-08-01
dc.description.abstractSeveral studies associated Major Depressive Disorder (MDD) with an increased production of pro-inflammatory cytokines, such as interleukin 6 (IL-6). Serum IL-6 levels were found to be significantly increased in subjects with MDD and with Treatment Resistant Depression (TRD). Moreover, ketamine, a drug with fast-acting antidepressant properties, has proven to reduce IL-6 levels in rat prefrontal cortex and hippocampus. However, despite the clear influence of IL-6 in the pathophysiology of depression and in antidepressant response, studies evaluating the impact of IL-6 functional genetic polymorphisms on treatment response phenotypes are scarce.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, M., Lima, L., Mota-Pereira, J., Cruz, A., Medeiros, R., Carvalho, S., Pimentel, P., Maia, D., Correia, D., & Gomes, S. (2014). EPA-1313—Influence of il6-174g>c, il6-6331t>c and il6r d358a a>c il-6 genetic polymorphisms in antidepressant treatment phenotypes. Abstracts of the 22nd European Congress of Psychiatry, 29, 1. https://doi.org/10.1016/S0924-9338(14)78532-3pt_PT
dc.identifier.doi10.1016/S0924-9338(14)78532-3pt_PT
dc.identifier.eissn1778-3585
dc.identifier.issn0924-9338
dc.identifier.urihttp://hdl.handle.net/10400.22/23539
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.titleInfluence of il6-174g>c, il6-6331t>c and il6r d358a a>c il-6 genetic polymorphisms in antidepressant treatment phenotypespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleEuropean Psychiatrypt_PT
oaire.citation.volume29 suplemento 1pt_PT
person.familyNameSantos
person.familyNameCruz
person.givenNameMarlene
person.givenNameAgostinho
person.identifier1508370
person.identifier.ciencia-id8311-B967-31C4
person.identifier.orcid0000-0001-5020-5942
person.identifier.orcid0000-0002-1157-8196
person.identifier.scopus-author-id57110502000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublicationd7ec3c5d-b3e0-4e34-8e24-4d1588876120
relation.isAuthorOfPublication.latestForDiscovery8ce9ee39-a4c6-46ae-99e2-49397b550f1b

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