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Fructose-Derived Carbon Dots as Selective Antitumor Agents in Breast Cancer Therapy: Synthesis, Characterization, and Biological Evaluation

2024Journal article Open access
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datacite.subject.fosEngenharia e Tecnologia::Nanotecnologia
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorMagalhães, Sofia
dc.contributor.authorLuís, Carla
dc.contributor.authorDuarte, Abel J.
dc.contributor.editorAdams, James David
dc.date.accessioned2025-04-24T11:43:50Z
dc.date.available2025-04-24T11:43:50Z
dc.date.issued2024
dc.description.abstractThis study explored a novel method using fructose-derived carbon dots (FCDs) for antitumor therapy in breast cancer (BC), marking a pioneering use of fructose as a carbon source for nanoparticle synthesis. BC, known for its complexity and heterogeneity, was chosen as a model due to its increasing mortality and incidence rates. The FCD synthesis involved the decomposition of fructose through microwave irradiation, followed by purification and characterization using techniques such as transmission electron microscopy, dynamic light scattering, fluorescence spectrophotometry, and Fourier-transform infrared spectroscopy. The FCDs, ranging in size from 2 to 6 nm, presented a hydrodynamic diameter below 2 nm, a spherical morphology, and a crystalline structure. As expected, FCDs were composed by carbon, oxygen, and hydrogen, and exhibited fluorescence with absorption and emission spectra at 405 nm and around 520 nm, respectively. Cell-based assays on breast epithelial and tumor cell lines demonstrated a dose-dependent response, with a decreased viability rate more pronounced in breast tumor cells. In conclusion, FCDs showed significant potential as selective antitumor agents for breast cancer therapy. The comprehensive characterization and cell-based assay evaluations provided valuable insights into the applications of these nanoparticles in breast cancer treatment, highlighting their selective toxicity and impact on tumor cells.eng
dc.description.sponsorshipThis research was partially supported by a scholarship awarded to Carla Luís (LPCC-NRN 2024). This work was supported by funding of the European Union (FEDER funds through Compete) and National Funds (FCT/MCTES) through Project LA/P/0008/2020 DOI 10.54499/LA/P/0008/2020, UIDP/50006/2020 DOI 10.54499/UIDP/50006/2020 and UIDB/50006/2020 DOI 10.54499/UIDB/ 50006/2020, UIDB/04730/2020 and UIDP/04730/2020.
dc.identifier.citationMagalhães, S., Luís, C., & Duarte, A. (2024). Fructose-Derived Carbon Dots as Selective Antitumor Agents in Breast Cancer Therapy: Synthesis, Characterization, and Biological Evaluation. J, 7(4), 584-591. https://doi.org/10.3390/j7040035
dc.identifier.doi10.3390/j7040035
dc.identifier.issn2571-8800
dc.identifier.urihttp://hdl.handle.net/10400.22/29997
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationCenter for Innovation in Industrial Engineering and Technology
dc.relationCenter for Innovation in Industrial Engineering and Technology
dc.relation.hasversionhttps://www.mdpi.com/2571-8800/7/4/35
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectcarbon dots
dc.subjectbreast cancer
dc.subjectfructose
dc.subjectfructose-derived carbon dots
dc.subjectnanotechnology
dc.titleFructose-Derived Carbon Dots as Selective Antitumor Agents in Breast Cancer Therapy: Synthesis, Characterization, and Biological Evaluationeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleCenter for Innovation in Industrial Engineering and Technology
oaire.awardTitleCenter for Innovation in Industrial Engineering and Technology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04730%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04730%2F2020/PT
oaire.citation.endPage591
oaire.citation.issue4
oaire.citation.startPage584
oaire.citation.titleJ - An Open Access Journal of Multidisciplinary Science (J)
oaire.citation.volume7
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLuís
person.familyNameDuarte
person.givenNameCarla
person.givenNameAbel J.
person.identifier.ciencia-id351E-8683-D4AF
person.identifier.ciencia-idD713-A799-54D3
person.identifier.orcid0000-0002-5292-6337
person.identifier.orcid0000-0003-0218-1952
person.identifier.ridD-8312-2013
person.identifier.scopus-author-id7102602124
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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