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From plants to psycho-neurology: unravelling the therapeutic benefits of bioactive compounds in brain disorders

2023-08-11Journal article Open access
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dc.contributor.authorGrosso, Clara
dc.contributor.authorSantos, Marlene
dc.contributor.authorBarroso, M. Fátima
dc.date.accessioned2023-09-18T15:51:17Z
dc.date.available2023-09-18T15:51:17Z
dc.date.issued2023-08-11
dc.description.abstractThe brain’s sensitivity to oxidative stress and neuronal cell death requires effective pharmacotherapy approaches. Current pharmacological therapies are frequently ineffective and display negative side effects. Bioactive chemicals found in plants may provide a potential alternative due to their antioxidant and neuroprotective properties and can be used in therapy and the management of a variety of neuropsychiatric, neurodevelopmental, and neurodegenerative illnesses. Several natural products, including vitamin C, Cammelia sinensis polyphenols, Hypericum perforatum, and Crocus sativus have shown promise in lowering oxidative stress and treating symptoms of major depressive disorder (MDD). Similarly, bioactive compounds such as curcumin, luteolin, resveratrol, quercetin, and plants like Acorus gramineus, Rhodiola rosea, and Ginkgo biloba are associated with neuroprotective effects and symptom improvement in neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). Furthermore, in neurodegenerative diseases, natural compounds from Rhodiola rosea, Morinda lucida, and Glutinous rehmannia provide neurological improvement. Further study in clinical samples is required to thoroughly investigate the therapeutic advantages of these bioactive substances for persons suffering from these illnesses.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGrosso, C., Santos, M., & Barroso, M. F. (2023). From Plants to Psycho-Neurology: Unravelling the Therapeutic Benefits of Bioactive Compounds in Brain Disorders. Antioxidants, 12(8), Artigo 8. https://doi.org/10.3390/antiox12081603pt_PT
dc.identifier.doi10.3390/antiox12081603pt_PT
dc.identifier.eissn2076-3921
dc.identifier.urihttp://hdl.handle.net/10400.22/23552
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-3921/12/8/1603pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectOxidative stresspt_PT
dc.subjectPsychiatric disorderspt_PT
dc.subjectNeurodevelopmental disorderspt_PT
dc.subjectNeurodegenerative disorderspt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectPlant-derived bioactive compoundspt_PT
dc.subjectAntioxidant activitypt_PT
dc.titleFrom plants to psycho-neurology: unravelling the therapeutic benefits of bioactive compounds in brain disorderspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage18pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleAntioxidantspt_PT
oaire.citation.volume12 (8)pt_PT
person.familyNameSantos
person.givenNameMarlene
person.identifier1508370
person.identifier.ciencia-id8311-B967-31C4
person.identifier.orcid0000-0001-5020-5942
person.identifier.scopus-author-id57110502000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublication.latestForDiscovery8ce9ee39-a4c6-46ae-99e2-49397b550f1b

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