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Increased susceptibility to Mycobacterium avium in hemochromatosis protein HFE-deficient mice

2008-10Journal article Open access
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dc.contributor.authorGomes Pereira, Sandra Isabel
dc.contributor.authorRodrigues, Pedro Nuno
dc.contributor.authorAppelberg, Rui
dc.contributor.authorGomes, Maria Salomé
dc.date.accessioned2021-09-28T08:27:55Z
dc.date.available2021-09-28T08:27:55Z
dc.date.issued2008-10
dc.description.abstractMycobacterium avium is an opportunistic infectious agent in immunocompromised patients, living inside macrophage phagosomes. As for other mycobacterial species, iron availability is a critical factor for M. avium survival and multiplication. Indeed, an association between host secondary iron overload and increased susceptibility to these mycobacteria is generally acknowledged. However, studies on the impact of primary iron overload on M. avium infection have not been performed. In this work, we used animal models of primary iron overload that mimic the human disease hereditary hemochromatosis. This pathology is characterized by increased serum transferrin saturation with iron deposition in parenchymal cells, mainly in the liver, and is most often associated with mutations in the gene encoding the molecule HFE. In this paper, we demonstrate that mice of two genetically determined primary iron overload phenotypes, Hfe(-/-) and beta 2m(-/-), show an increased susceptibility to experimental infection with M. avium and that during infection these animals accumulate iron inside granuloma macrophages. beta 2m(-/-) mice were found to be more susceptible than Hfe(-/-) mice, but depleting Hfe(-/-) mice of CD8(+) cells had no effect on resistance to infection. Overall, our results suggest that serum iron, rather than total liver iron, levels have a considerable impact on susceptibility to M. avium infection.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGomes-Pereira, S., Rodrigues, P. N., Appelberg, R., & Gomes, M. S. (2008). Increased susceptibility to mycobacterium avium in hemochromatosis protein HFE-deficient mice. Infection and immunity, 76(10), 4713-4719. https://doi.org/doi:10.1128/IAI.00612-08pt_PT
dc.identifier.doi10.1128/IAI.00612-08pt_PT
dc.identifier.issn1098-5522
dc.identifier.urihttp://hdl.handle.net/10400.22/18586
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherASM Journalspt_PT
dc.relation.publisherversionhttps://journals.asm.org/doi/10.1128/IAI.00612-08pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectIron overloadpt_PT
dc.subjectTuberculosis infectionpt_PT
dc.subjectT-Cellspt_PT
dc.subjectTransferrinpt_PT
dc.subjectInterferonpt_PT
dc.subjectResistancept_PT
dc.subjectMonocytespt_PT
dc.subjectImmunitypt_PT
dc.subjectGrowthpt_PT
dc.subjectGammapt_PT
dc.titleIncreased susceptibility to Mycobacterium avium in hemochromatosis protein HFE-deficient micept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4719pt_PT
oaire.citation.startPage4713pt_PT
oaire.citation.titleInfection and Immunitypt_PT
oaire.citation.volume76pt_PT
person.familyNameGomes Pereira
person.givenNameSandra Isabel
person.identifier.ciencia-id511C-D166-B855
person.identifier.orcid0000-0002-3995-5790
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1afef94e-0633-4ee4-bb6b-1a3ecf7366d2
relation.isAuthorOfPublication.latestForDiscovery1afef94e-0633-4ee4-bb6b-1a3ecf7366d2

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