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Cytochrome P450 polymorphisms with impact in cardiovascular drugs metabolisms in European populations

2022-09Journal article Restricted access
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dc.contributor.authorMorais, Stephanie L.
dc.contributor.authorGonçalves, Tiago F.C.
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorFerrreira-Fernandes, Hygor
dc.contributor.authorPinto, Giovanny R.
dc.contributor.authorDomingues, Valentina F.
dc.contributor.authorBarroso, M. Fátima
dc.date.accessioned2023-01-27T11:13:26Z
dc.date.embargo2035
dc.date.issued2022-09
dc.description.abstractThe cytochrome P450 (CYP) enzymes constitute a large polymorphic family that play a huge role in the metabolism of endogenous compounds and in the metabolization of 70–80% of all clinically prescribed medications. Among them, the CYP2C9, CYP2C19, CYP2D6 and CYP4F2 genes are of clinical relevance, as they are highly polymorphic and implicated in the metabolism of several drugs. These genetic polymorphisms which induce variability in CYPs expression present qualitative and quantitative differences between ethnic groups and geographic regions. This review aims to evaluate the allele frequencies, genotypic distribution and predicted CYP2C9, CYP2C19, CYP2D6 and CYP4F2 genetic variants in the European countries. Therefore, a PubMed and a Web of Science search from 1989 to 2021 on the data on the polymorphic prevalence among European countries of the CYP2C9, CYP2C19, CYP2D6 and CYP4F2 genes was performed. After excluding the duplicates, a total of 1179 studies were found. The results were structured and presented in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The present paper is an overview on the frequency CYP genetic variations, facilitating the prediction of a patient's response to medication and, consequently, enabling the selection of personalized medicinept_PT
dc.description.sponsorshipThis work was funded by the Bilateral Cooperation FCT/CAPES 2018/2019 Processo 4.4.1.00 CAPES (CAPES-FCT2017484310P 200.137.174.210). This work was also supported by UIDB/50006/2020 and UIDP/50006/2020 by the Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through national funds. M. F. Barroso thanks FCT for the FCT Investigator (ref.2020.03107.CEECIND)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.humgen.2022.201027pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/21938
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relationCAPES-FCT2017484310P 200.137.174.210pt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationChallenging the Attention-Deficit / Hyperactivity Disorder (ADHD) diagnosis: Moving towards sensitive electrochemical miRNA biosensing
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2773044122000018?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCYP2C9pt_PT
dc.subjectCYP2C19pt_PT
dc.subjectCYP2D6pt_PT
dc.subjectCYP4F2pt_PT
dc.subjectEuropean populationspt_PT
dc.subjectGenetic polymorphismpt_PT
dc.titleCytochrome P450 polymorphisms with impact in cardiovascular drugs metabolisms in European populationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleChallenging the Attention-Deficit / Hyperactivity Disorder (ADHD) diagnosis: Moving towards sensitive electrochemical miRNA biosensing
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 3ed/2020.03107.CEECIND%2FCP1596%2FCT0005/PT
oaire.citation.startPage201027pt_PT
oaire.citation.titleHuman Genept_PT
oaire.citation.volume33pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 3ed
person.familyNameDelerue-Matos
person.familyNameDomingues
person.familyNamede Sá Barroso
person.givenNameCristina
person.givenNameValentina Maria Fernandes
person.givenNameMaria de Fátima
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.ciencia-id4E16-791D-6664
person.identifier.ciencia-idAF16-22E5-5EBD
person.identifier.orcid0000-0002-3924-776X
person.identifier.orcid0000-0003-3472-849X
person.identifier.orcid0000-0001-9011-5992
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id6603741848
person.identifier.scopus-author-id25631648000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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