Publication
The role of extracellular vesicles-derived microRNAs in the development of renal cell carcinoma
| dc.contributor.advisor | Teixeira, Ana Luísa Pereira | |
| dc.contributor.advisor | Santos, Marlene Elisabete Moreira | |
| dc.contributor.author | Venâncio, Patrícia Sofia Almeida | |
| dc.date.accessioned | 2024-01-29T15:25:25Z | |
| dc.date.available | 2024-05-08T00:31:07Z | |
| dc.date.issued | 2023-11-08 | |
| dc.description.abstract | Renal cell carcinoma (RCC) is the most common and most lethal urological neoplasia amongst adults. In fact, approximately one-third of the patients are diagnosed with metastatic disease and approximately 20-30% will develop metastasis even after surgical nephrectomy. It is known that EVs play a crucial role in the tumour microenvironment establishment and are involved in the metastatic process. Thus, the aim of this study was to analyze an EV-derived miRNA profile associated with clear cell RCC (ccRCC) development and its role on the cell phenotype modulation. We analyzed a five-miRNA profile in EVs derived from tumoural RCC cell lines (tumoural vs normal) that represented different stages of ccRCC progression. We observed an increase in hsa-miR-571 and hsa-miR-3074-3p levels in EVs derived from metastatic cell line, FG-2, when compared to the control which led to a decrease in the RAD51mRNA expression levels. Additionally, we verified that the administration of EVs-FG-2 to the normal cell line led to a decreased cellular proliferation and migration of the recipient cell line. In conclusion, EVs-FG-2 carry hsa-miR-571 and hsa-miR-3074-3p acting as suppressors of tumour development. | pt_PT |
| dc.identifier.tid | 203474732 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.22/24804 | |
| dc.language.iso | eng | pt_PT |
| dc.subject | Renal cell carcinoma | pt_PT |
| dc.subject | RCC | pt_PT |
| dc.subject | Extracellular vesicles | pt_PT |
| dc.subject | EVs | pt_PT |
| dc.subject | EV-derived mirRNAs | pt_PT |
| dc.title | The role of extracellular vesicles-derived microRNAs in the development of renal cell carcinoma | pt_PT |
| dc.type | master thesis | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | masterThesis | pt_PT |
| thesis.degree.name | Farmácia | pt_PT |
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