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Identification of Eschweilenol C in derivative of Terminalia fagifolia Mart. and green synthesis of bioactive and biocompatible silver nanoparticles

2019-10-01Journal article Open access
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dc.contributor.authorAraujo, Alyne Rodrigues de
dc.contributor.authorRamos-Jesus, Joilson
dc.contributor.authorOliveira, Taiane Maria de
dc.contributor.authorCarvalho, Andressa Maria A. de
dc.contributor.authorNunes, Paulo Humberto M.
dc.contributor.authorDaboit, Tatiane Caroline
dc.contributor.authorCarvalho, Ana P.
dc.contributor.authorBarroso, M. Fátima
dc.contributor.authorAlmeida, Miguel Peixoto de
dc.contributor.authorPlácido, Alexandra
dc.contributor.authorRodrigues, Artur
dc.contributor.authorPortugal, Camila C.
dc.contributor.authorSocodato, Renato
dc.contributor.authorRelvas, João B.
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorSilva, Durcilene Alves da
dc.contributor.authorEaton, Peter
dc.contributor.authorLeite, José Roberto de Souza de A.
dc.date.accessioned2020-07-10T13:09:50Z
dc.date.available2020-07-10T13:09:50Z
dc.date.issued2019-10-01
dc.description.abstractA green synthetic route was developed to prepare silver nanoparticles (AgNPs) in aqueous solution for biological applications. Eschweilenol C, a compound derivative ellagic acid was identified as the main constituent of the aqueous fraction of the ethanolic extract of Terminalia fagifolia Mart. by NMR analysis. In the green synthesis, the ethanolic extract of T. fagifolia and its aqueous fraction were used to promote silver reduction and nanoparticle stabilization. The synthesized AgNPs presented a spherical or polygonal morphology shape by TEM analysis and AgNPs showed high levels of antioxidant and considerable antibacterial and antifungal activities. Synthesized nanoparticles presented significant antioxidant activity by sequestration of DPPH and ABTS radicals, in addition to iron reduction (FRAP assay) and measurement of antioxidant capacity in ORAC units, in addition, AgNP synthesized with the aqueous fraction also demonstrated antioxidant potential in microglial cells. Gram-positive and Gram-negative bacteria were susceptible to growth inhibition by the nanoparticles, among which the AgNPs formed by the ethanolic extract was the most effective. The data obtained by AFM images suggested that AgNPs could lead to the lysis of bacteria and subsequent death. The antifungal assays showed high efficiency against yeasts and dermatophytes. This work represents the first description of antifungal activity by AgNPs against Fonsecaea pedrosoi, the etiologic agent of chromoblastomycosis. In relation to biocompatibility, the AgNPs induced lower haemolysis than AgNO3.pt_PT
dc.description.sponsorshipWe thank Herbert Kogler and Reinhard Wimmer for the identification of Eschweilenol C. The NMR laboratory at Aalborg University is supported by the Obel Family, SparNord and Carlsberg foundations.The authors are grateful to Carla Eiras (LIMAV/CT/UFPI) and to FCT and EU for financial support through project UID/QUI/50006/2013– POCI-01-0145-FEDER-007265 from COMPETE and projectNORTE-01-0145-FEDER-000011 from COMPETE. Thanks to Andreia Pinto for help with the TEM measurements at Instituto de Medicina Molecular (IMM). This work was supported by the Histology and Comparative Pathology Laboratory of the IMMpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.indcrop.2019.05.012pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/16092
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0926669019303371?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectEllagic acidpt_PT
dc.subjectMetallic nanoparticlespt_PT
dc.subjectTerminalia sppt_PT
dc.subjectAntioxidantpt_PT
dc.subjectAntimicrobialpt_PT
dc.subjectFonsecaea pedrosoipt_PT
dc.titleIdentification of Eschweilenol C in derivative of Terminalia fagifolia Mart. and green synthesis of bioactive and biocompatible silver nanoparticlespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.citation.endPage65pt_PT
oaire.citation.startPage52pt_PT
oaire.citation.titleIndustrial Crops and Productspt_PT
oaire.citation.volume137pt_PT
oaire.fundingStream5876
person.familyNameCarvalho
person.familyNamede Sá Barroso
person.familyNameDelerue-Matos
person.givenNameAna
person.givenNameMaria de Fátima
person.givenNameCristina
person.identifierK-5479-2013
person.identifier.ciencia-id6F1E-301F-71BA
person.identifier.ciencia-idAF16-22E5-5EBD
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0001-5967-4200
person.identifier.orcid0000-0001-9011-5992
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridK-5479-2013
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id36855267200
person.identifier.scopus-author-id25631648000
person.identifier.scopus-author-id6603741848
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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