Publication
Bonding to Psychedelics: Synthesis of Molecularly Imprinted Polymers Targeting 4-Bromo-2,5-dimethoxyphenethylamine (2C-B)
| datacite.subject.fos | Engenharia e Tecnologia | |
| datacite.subject.sdg | 09:Indústria, Inovação e Infraestruturas | |
| dc.contributor.author | Martins, Daniel | |
| dc.contributor.author | Fernandes, Carlos | |
| dc.contributor.author | Mendes, Ricardo F. | |
| dc.contributor.author | Cagide, Fernando | |
| dc.contributor.author | Silva, António Fernando | |
| dc.contributor.author | Borges, Fernanda | |
| dc.contributor.author | Garrido, Jorge | |
| dc.contributor.author | Garrido, Jorge | |
| dc.date.accessioned | 2025-02-11T12:13:20Z | |
| dc.date.available | 2025-02-11T12:13:20Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | The increasing interest in utilizing psychedelics for therapeutic purposes demands the development of tools capable of efficiently monitoring and accurately identifying these substances, thereby supporting medical interventions. 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) has gained significant popularity as one of the most widely used psychedelic compounds in non-medical settings. In this study, we aimed to create a material with selective recognition of 2C-B by synthesizing a series of molecularly imprinted polymers (MIP) using 2C-B as the template and varying ratios of methacrylic acid (MAA) as the functional monomer (1:2, 1:3, and 1:4). Both thermal and microwave-assisted polymerization processes were employed. The molar ratio between the template molecule (2C-B) and functional monomer (MAA) was 1:4, utilizing a microwave-assisted polymerization process. Isotherm studies revealed a Langmuir’s maximum absorption capacity (Bmax) value of 115.6 μmol·mg−1 and Kd values of 26.7 μM for this material. An imprint factor of 4.2 was determined for this material, against the corresponding non-imprinted polymer. The good selectivity against 14 other new psychoactive substances highlighted the material’s potential for applications requiring selective recognition. These findings can contribute to the development of tailored materials for the detection and analysis of 2C-B, supporting advancements in non-medical use monitoring and potential therapeutic models involving psychedelics. | eng |
| dc.description.sponsorship | This work was funded by FEDER funds through the Operational Programme Competitiveness Factors-COMPETE and national funds from the FCT, Foundation for Science and Technology, under research grants (Grants UIDB/00081/2020 (CIQUP), LA/P/0056/2020 (IMS). The D. Martins (PD/BD/135122/2017) grant and FC, CF [CEECIND/00823/2021], contracts are supported by FCT and FEDER/COMPETE. This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020, UIDP/50011/2020, and LA/P/0006/2020, financed by national funds through the FCT/MCTES (PIDDAC). RM gratefully acknowledges FCT for a Junior Research Position (CEECIND/00553/2017). | |
| dc.identifier.citation | Martins, D., Fernandes, C., Mendes, R. F., Cagide, F., Silva, A. F., Borges, F., & Garrido, J. (2024). Bonding to Psychedelics: Synthesis of Molecularly Imprinted Polymers Targeting 4-Bromo-2,5-dimethoxyphenethylamine (2C-B). Applied Sciences, 14(4), 1377. https://doi.org/10.3390/app14041377 | |
| dc.identifier.doi | 10.3390/app14041377 | |
| dc.identifier.issn | 2076-3417 | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/29458 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation | CICECO-Aveiro Institute of Materials | |
| dc.relation | CICECO-Aveiro Institute of Materials | |
| dc.relation.hasversion | https://www.mdpi.com/2076-3417/14/4/1377 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | psychedelic drugs | |
| dc.subject | 2C-B | |
| dc.subject | molecularly-imprinted polymer | |
| dc.subject | microwave-assisted synthesis | |
| dc.subject | selectivity | |
| dc.title | Bonding to Psychedelics: Synthesis of Molecularly Imprinted Polymers Targeting 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | CICECO-Aveiro Institute of Materials | |
| oaire.awardTitle | CICECO-Aveiro Institute of Materials | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50011%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50011%2F2020/PT | |
| oaire.citation.issue | 4 | |
| oaire.citation.title | Applied Sciences | |
| oaire.citation.volume | 14 | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| person.familyName | Garrido | |
| person.givenName | Jorge | |
| person.identifier.orcid | 0000-0002-1317-2819 | |
| person.identifier.orcid | 0000-0002-0102-0703 | |
| person.identifier.orcid | 0000-0001-8242-324X | |
| person.identifier.orcid | 0000-0001-9410-6874 | |
| person.identifier.orcid | 0000-0003-1050-2402 | |
| person.identifier.orcid | 0000-0001-8981-231X | |
| person.identifier.orcid | 0000-0001-8981-231X | |
| person.identifier.scopus-author-id | 7202779733 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
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