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Advisor(s)
Abstract(s)
The present work aims to share the process of development of advanced biological
models to study radiobiological effects.
Recognizing several known limitations and difficulties of the current monolayer cellular
models, as well as the increasing difficulties to use advanced biological models, our
group has been developing advanced biological alternative models, namely three-
dimensional cell cultures and a less explored animal model (the Zebrafish - Danio rerio
- which allows the access to inter-generational data, while characterized by a great
genetic homology towards the humans). These three models (monolayer cellular
model, three-dimensional cell cultures and zebrafish) were externally irradiated with
100mGy, 500mGy or 1Gy. The consequences of that irradiation were studied using
cellular and molecular tests.