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Methamphetamine mimics the neurochemical profile of aging in rats and impairs recognition memory

2012Journal article Open access
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dc.contributor.authorMelo, Pedro
dc.contributor.authorMagalhães, Ana
dc.contributor.authorAlves, Cecília J.
dc.contributor.authorTavares, Maria Amélia
dc.contributor.authorSousa, Liliana de
dc.contributor.authorSummavielle, Teresa
dc.contributor.authorMoradas-Ferreira, Pedro
dc.date.accessioned2018-11-26T15:52:11Z
dc.date.available2018-11-26T15:52:11Z
dc.date.issued2012
dc.description.abstractBrain neurochemistry and cognition performance are thought to decline with age. Accumulating data indicate that similar events occur after prolonged methamphetamine (MA) exposure. Using the rat as a model, the present study was designed to uncover common alteration patterns in brain neurochemistry and memory performance between aging and prolonged MA exposure. To this end, animals were treated with a chronic binge MA administration paradigm (20 mg/kg/day from postnatal day 91 to 100). Three-age control groups received isovolumetric saline treatment and were tested at the MA age-matched period, and at 12 and 20 months. We observed that both MA and aged animals presented a long, but not short, time impairment in novelty preference and an increased anxiety-like behavior. Neurochemical analysis indicated similar MA- and age-related impairments in dopamine, serotonin and metabolites in the striatum, prefrontal cortex and hippocampus. Thus, the present data illustrate that MA may be used to mimic age-related effects on neurotransmitter systems and advocate MA treatment as a feasible animal model to study neuronal processes associated with aging.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMelo, P., Magalhães, A., Alves, C. J., Tavares, M. A., de Sousa, L., Summavielle, T., & Moradas-Ferreira, P. (2012). Methamphetamine mimics the neurochemical profile of aging in rats and impairs recognition memory. NeuroToxicology, 33(3), 491–499. https://doi.org/10.1016/j.neuro.2012.03.002pt_PT
dc.identifier.doi10.1016/j.neuro.2012.03.002pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/12283
dc.language.isoporpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0161813X12000654pt_PT
dc.subjectMetanfetaminapt_PT
dc.subjectEnvelhecimentopt_PT
dc.subjectNeuroquímicapt_PT
dc.subjectMemóriapt_PT
dc.titleMethamphetamine mimics the neurochemical profile of aging in rats and impairs recognition memorypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage499pt_PT
oaire.citation.startPage491pt_PT
oaire.citation.titleNeuroToxicologypt_PT
oaire.citation.volume33pt_PT
person.familyNameMartins de Almeida Melo
person.familyNameAlves
person.familyNameSummavielle
person.givenNamePedro Miguel
person.givenNameCecília Juliana
person.givenNameTeresa
person.identifier677706
person.identifier.ciencia-idCC17-D6DA-41CA
person.identifier.ciencia-id3911-5277-41E1
person.identifier.ciencia-idC41E-0816-5C85
person.identifier.orcid0000-0003-0590-0684
person.identifier.orcid0000-0002-0719-574X
person.identifier.orcid0000-0003-2548-6281
person.identifier.ridC-9776-2012
person.identifier.scopus-author-id7102051985
person.identifier.scopus-author-id6603092949
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione55c4fc5-819f-4b76-80ab-819cf3aa0037
relation.isAuthorOfPublicationac966b97-32d2-4022-87d9-36b5a8924d56
relation.isAuthorOfPublication207ee2de-85a0-4144-9e7e-b376c600e065
relation.isAuthorOfPublication.latestForDiscovery207ee2de-85a0-4144-9e7e-b376c600e065

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