Logo do repositório
 
Publicação

Metabolism-targeted therapy in NSCLC – A new theranostics inhalation approach using lactate functionalized and selenium-chrysin loaded nanoparticles (SeChry@PUREG4-LA24)

2025-09Artigo de investigação Acesso aberto
Ver registo simples
dc.contributor.authorMendes, Cindy
dc.contributor.authorMartins, Filipa
dc.contributor.authorGranja, Sara
dc.contributor.authorGonçalves, Joana
dc.contributor.authorBarros, Hélio
dc.contributor.authorCasimiro, Teresa
dc.contributor.authorRicardo, Ana Aguiar
dc.contributor.authorSilva, Fernanda
dc.contributor.authorAbreu, Bruna
dc.contributor.authorCristovão, Miguel
dc.contributor.authorAndré, Saudade
dc.contributor.authorPereira, Sofia A.
dc.contributor.authorBaltazar, Fátima
dc.contributor.authorMarques, Helena Cabral
dc.contributor.authorGaspar, Maria Manuela
dc.contributor.authorGonçalves, Luís G.
dc.contributor.authorBonifácio, Vasco D. B.
dc.contributor.authorSerpa, Jacinta
dc.contributor.authorGranja, Sara
dc.date.accessioned2026-01-15T14:40:13Z
dc.date.available2026-01-15T14:40:13Z
dc.date.issued2025-09
dc.description.abstractLung cancer is one of the most lethal cancers globally, primarily due to delayed diagnosis and lack of specific and effective therapy. Increased lactate production and consumption, along with cysteine metabolic reliance, are features identified in NSCLC in our recent studies. Cancer metabolic remodeling leads to excessive ROS production, triggering oxidative stress, promoting angiogenesis, causing cellular and tissue damage, and contributing to various pathophysiological changes. This study aimed to investigate the therapeutic potential of selenium–chrysin (SeChry), a cysteine metabolism inhibitor, and its delivery targeted at MCT1 by encapsulation in fourth-generation polyurea dendrimers functionalized with lactic acid (PUREG4-LA24), the nanoformulation SeChry@PUREG4-LA24, in NSCLC. We explored the impact of SeChry nanoformulation on cell death mechanisms, including ferroptosis, and its influence on angiogenesis in in vitro and in vivo models. SeChry@PUREG4-LA24 induces cell death through the induction of intracellular ROS and lipid peroxides, resulting in distinct expression patterns of ferroptosis-associated genes across cell lines. Experiments using chicken embryo chorioallantoic membrane (CAM) and mouse orthotopic xenograft models revealed a trend toward decreased tumor growth and angiogenesis with SeChry@PUREG4-LA24 administration. These findings suggest the potential of SeChry@PUREG4-LA24 as an innovative therapeutic approach for NSCLC, highlighting its impact on cell death mechanisms and anti-angiogenic effects.eng
dc.identifier.citationMendes, C., Martins, F., Granja, S., Gonçalves, J., Barros, H., Casimiro, T., Aguiar-Ricardo, A., Silva, F., Abreu, B., Cristovão, M., André, S., Pereira, S. A., Baltazar, F., Cabral-Marques, H., Gaspar, M. M., Gonçalves, L. G., Bonifácio, V. D. B., & Serpa, J. (2025). Metabolism-targeted therapy in NSCLC – A new theranostics inhalation approach using lactate functionalized and selenium-chrysin loaded nanoparticles (SeChry@PUREG4-LA24). Biomedicine & Pharmacotherapy, 190, 118405. https://doi.org/10.1016/j.biopha.2025.118405
dc.identifier.doi10.1016/j.biopha.2025.118405
dc.identifier.eissn1950-6007
dc.identifier.issn0753-3322
dc.identifier.urihttp://hdl.handle.net/10400.22/31537
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationUIDB/04462/2020 and UIDP/04462/2020), to MOSTMICRO-ITQB (UIDB/04612/2020 and UIDP/04612/2020) and the Associated Laboratory LS4FUTURE (LA/P/ 0087/2020
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0753332225005992?via%3Dihub
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectNon-small-cell lung carcinoma (NSCLC)
dc.subjectMetabolic remodeling
dc.subjectSelenium-containing chrysin (SeChry)
dc.subjectFourth-generation polyurea dendrimer functionalized with lactic acid (PUREG4-LA24)
dc.subjectReactive oxygen species (ROS)
dc.subjectOxidative stress-induced ferroptosis
dc.subjectMetabolism-directed therapy
dc.titleMetabolism-targeted therapy in NSCLC – A new theranostics inhalation approach using lactate functionalized and selenium-chrysin loaded nanoparticles (SeChry@PUREG4-LA24)eng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.titleBiomedicine & Pharmacotherapy
oaire.citation.volume190
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGranja
person.givenNameSara
person.identifier.ciencia-idC41F-02E4-065E
person.identifier.orcid0000-0001-8717-6751
relation.isAuthorOfPublication06306a95-9c06-47c7-b2e5-5bbf757bec17
relation.isAuthorOfPublication.latestForDiscovery06306a95-9c06-47c7-b2e5-5bbf757bec17

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
ART_Sara Granja.pdf
Tamanho:
10.24 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
4.03 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

ESS - APCT - Artigos
ESS - CISA - Artigos