Repository logo
 
Publication

Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae-Derived Compounds with Neuroprotective Activity: A Comprehensive Review

dc.contributor.authorMartins, Bruna
dc.contributor.authorVieira, Mónica
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorGrosso, Clara
dc.contributor.authorSoares, Cristina
dc.date.accessioned2023-01-30T11:14:58Z
dc.date.available2023-01-30T11:14:58Z
dc.date.issued2022-05-28
dc.description.abstractCurrently, there is no known cure for neurodegenerative disease. However, the available therapies aim to manage some of the symptoms of the disease. Human neurodegenerative diseases are a heterogeneous group of illnesses characterized by progressive loss of neuronal cells and nervous system dysfunction related to several mechanisms such as protein aggregation, neuroinflammation, oxidative stress, and neurotransmission dysfunction. Neuroprotective compounds are essential in the prevention and management of neurodegenerative diseases. This review will focus on the neurodegeneration mechanisms and the compounds (proteins, polyunsaturated fatty acids (PUFAs), polysaccharides, carotenoids, phycobiliproteins, phenolic compounds, among others) present in seaweeds that have shown in vivo and in vitro neuroprotective activity. Additionally, it will cover the recent findings on the neuroprotective effects of bioactive compounds from macroalgae, with a focus on their biological potential and possible mechanism of action, including microbiota modulation. Furthermore, gastrointestinal digestion, absorption, and bioavailability will be discussed. Moreover, the clinical trials using seaweed-based drugs or extracts to treat neurodegenerative disorders will be presented, showing the real potential and limitations that a specific metabolite or extract may have as a new therapeutic agent considering the recent approval of a seaweed-based drug to treat Alzheimer’s diseasept_PT
dc.description.sponsorshipThis work was financed by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalisation (POCI), and by Portuguese funds through FCT—Fundação para a Ciência e a Tecnologia in the framework of the project POCI-01-0145-FEDER-030240—PTDC/OCE-ETA/30240/2017—SilverBrain-From sea to brain: Green neuroprotective extracts for nanoencapsulation and functional food production. This work was supported by projects REQUIMTE/LAQV—UIDB/50006/2020, UIDP/50006/2020, and LA/P/0008/2020 financed by FCT/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES), through national fundspt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/md20060362pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/21990
dc.language.isoengpt_PT
dc.publisherMDPIpt_PT
dc.relationPOCI-01-0145-FEDER-030240pt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relation.publisherversionhttps://www.mdpi.com/1660-3397/20/6/362pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAlzheimer’s diseasept_PT
dc.subjectHuntington’s diseasept_PT
dc.subjectNeuroprotectionpt_PT
dc.subjectParkinson’s diseasept_PT
dc.subjectSeaweedspt_PT
dc.titleBiological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae-Derived Compounds with Neuroprotective Activity: A Comprehensive Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FOCE-ETA%2F30240%2F2017/PT
oaire.citation.issue6pt_PT
oaire.citation.startPage362pt_PT
oaire.citation.titleMarine Drugspt_PT
oaire.citation.volume20pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream9471 - RIDTI
person.familyNameDelerue-Matos
person.familyNameGrosso
person.familyNameDias Soares
person.givenNameCristina
person.givenNameAna Clara
person.givenNameCristina Maria
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.ciencia-id711B-1170-4C32
person.identifier.ciencia-id5016-4F99-C69D
person.identifier.orcid0000-0002-3924-776X
person.identifier.orcid0000-0002-2457-8267
person.identifier.orcid0000-0003-0924-9681
person.identifier.ridD-4990-2013
person.identifier.ridB-9813-2013
person.identifier.scopus-author-id6603741848
person.identifier.scopus-author-id25627935200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublicationf8a4443b-2748-4523-8219-691d0523d467
relation.isAuthorOfPublication72b9814d-0e56-42e0-a1d7-93cb47fb9ae0
relation.isAuthorOfPublication.latestForDiscovery09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isProjectOfPublicationfc4a587f-c16e-4777-9549-2da7a1cf7d0e
relation.isProjectOfPublication484b2b57-f7aa-41f2-a5b5-38852a419aec
relation.isProjectOfPublication6a1d7665-e44e-4a7a-adde-61887d9ca629
relation.isProjectOfPublication.latestForDiscoveryfc4a587f-c16e-4777-9549-2da7a1cf7d0e

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Marine Drugs 20 (6) (2022) 362.pdf
Size:
1.57 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: